A 76-year-old female during the treatment of nontuberculous mycobacterium (NTM) (Mycobacterium avium complex infection) was admitted to our hospital complained of bloody sputum and low-grade fever for last six days. She had a past history of mitral valve replacement operation, and warfarin and low dose of aspirin were administrated as anti-coagulant therapy. In addition, clarithromycin, ethambutol, and rifampicin were also administrated for the treatment of NTM. Three days before consulting our outpatient clinic, she consulted her primary care physician and was treated with clavulanic acid/amoxicillin for 3 days. However, her bloody sputum was continued, and she consulted our outpatient clinic. Chest computed tomography (CT) imaging showed tree-in-bud appearance (bronchiolitis) with right upper lobe and consolidative shadow with left upper lobe (Figure 1A). Computed tomography showed consolidation in left upper lobe (Figure 1A). In left main bronchus, high-density plugged sputum was observed [high-attenuation mucus (HAM)] (Figure 1B and Figure 1C). Sputum bacterial culture test utilizing matrix assisted laser desorption/ionization time-of-flight mass spectrometer showed Aspergillus fumigatus. Mycobacterium avium complex was also confirmed. Sputum cytological examination showed Aspergillus hyphae. Blood examination showed as following: white blood cell count was 4980/μL (eosinophil 8.0%, lymphocyte 35.1%, and neutrophil 57.5%), hemoglobin 13.8 g/dL, platelet count 179,000/μL, C-reactive protein 0.37 mg/dL, immunoglobulin E radioallergosorbent testing (IgE RAST) 440 IU/mL, aspergillus RAST 2.59 (class 2), anti-aspergillus antigen 0.1, β-D glucan 7.1 pg/mL. As long as we confirmed, she did not have a past history of bronchial asthma. Bronchofiberscopic examination was performed and aspirated viscous purulent sputum from left lower trunk bronchus (Figure 2). Sputum bacterial culture test showed A. fumigatus. The diagnosis of allergic bronchopulmonary aspergillosis (ABPA) was performed, and administration of 0.5 mg/kg/day of prednisolone was started. Eosinophilia, high IgE-titer, and her symptoms were gradually improved.

Allergic bronchopulmonary aspergillosis is known as lower respiratory tract inflammation derived from type I and III/IV allergic reaction against A. fumigatus [1]. Allergic bronchopulmonary aspergillosis complicated with bronchial asthma or cystic fibrosis, but NTM is also reported as complication ABPA [1]. Since irreversible fibrotic change and severe bronchiectasis were progressed in advance case, diagnosis of ABPA in earlier stage is important. But it is difficult in case of without bronchial asthma like this case. From 20% to 30% of ABPA case, HAM with chest CT was confirmed, and that is realized for specific findings with ABPA [1],[2]. High-attenuation mucus is realized as sputum plug showing higher CT intensity than that of skeletal muscle. Components of iron and calcium are the cause of higher intensity of sputum plug ABPA [2].

A rare case of ABPA with NTM was reported. HAM was useful for the diagnosis. As the cause of bloody sputum with NTM, possibility of ABPA should be considered as the differential diagnosis.