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Case Report
Membranous nephropathy (MN) concurrent chronic inflammatory demyelinating polyneuropathy (CIDP) in a Bangladeshi male
1 Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
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Md Gias Uddin
Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University, Dhaka,
Bangladesh
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Article ID: 101520Z01MU2025
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Gias Uddin M, Hassan MM, Sohel M, Azad MAK, Hussain KH, Choudhory MR. Membranous nephropathy (MN) concurrent chronic inflammatory demyelinating polyneuropathy (CIDP) in a Bangladeshi male. Int J Case Rep Images 2025;16(2):40–45.ABSTRACT
Introduction: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired autoimmune disorder of the peripheral nervous system, while membranous nephropathy (MN) is a glomerular disease that may develop from exogenous risks or autoimmune conditions. Their coexistence is extremely rare and poorly understood.
Case Report: We report a 55-year-old male from Bangladesh presenting with progressive symmetrical muscle weakness and both motor and sensory impairment in all four limbs. Nerve conduction studies demonstrated features consistent with inflammatory demyelinating polyneuropathy, and cerebrospinal fluid analysis revealed albuminocytological dissociation. The patient also developed nephrotic-range proteinuria; renal biopsy confirmed the diagnosis of membranous nephropathy. He was treated with pulse methylprednisolone and intravenous cyclophosphamide, resulting in improvement in both muscle strength and proteinuria, though sensory deficits persisted.
Conclusion: This rare case of concurrent CIDP and MN suggests a shared autoimmune mechanism involving nerves and kidneys. Early recognition and treatment are essential to prevent irreversible neurological and renal damage, especially in resource-limited settings.
Keywords: Autoimmune overlap syndrome, CIDP, Cyclophosphamide, Membranous nephropathy
SUPPORTING INFORMATION
Author Contributions
Md Gias Uddin - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Md Masudul Hassan - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mainuddin Sohel - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mohammad Abul Kalam Azad - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Kassim Hagi Hussain - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Minhaj Rahim Choudhory - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Md Gias Uddin et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
