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Case Report
Corneal edema from amantadine toxicity in child with fetal alcohol syndrome
1 Associate Professor, Department of Psychiatry, KU Medical Center, Kansas City, KS, USA
2 MD candidate 2025, University of Kansas School of Medicine, Kansas City KS, USA
Address correspondence to:
Ann C Genovese
MD, 3901 Rainbow Blvd, Kansas City, KS 66160,
USA
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Article ID: 101512Z01AG2025
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Genovese AC, Longhi S. Corneal edema from amantadine toxicity in child with fetal alcohol syndrome. Int J Case Rep Images 2025;16(2):1–6.ABSTRACT
Amantadine has been used in both neurology and psychiatry for an increasingly wide array of clinical indications, often with significant success in managing difficult-to-treat neurological, developmental, and psychiatric disorders with ongoing research into its potential benefit for many more, often entirely unrelated health conditions. The authors summarize the literature to date which describes corneal edema as a less well-known potential adverse effect of this medication, particularly in children and adolescents. We present a case in which the timely identification of bilateral corneal edema for a child taking amantadine over the course of three years for the treatment of psychiatric and behavioral problems associated with fetal alcohol syndrome, who has resolution of corneal edema following amantadine discontinuation.
Keywords: Amantadine toxicity, Corneal edema, Fetal alcohol syndrome
SUPPORTING INFORMATION
Author Contributions
Ann C Genovese - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Simon Longhi - Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Ann C Genovese et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
