Case Report


The evaluation, diagnosis, and treatment of malignant mixed Müllerian tumor of the cervix: A case report

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1 MD (General Medicine), Senior Resident, Department of Medical Oncology, Institute of Obstetrics and Gynaecology, Egmore, Tamil Nadu, India

2 MSc, Clinical Oncology, Junior Resident, Department of Medical Oncology, Institute of Obstetrics and Gynaecology, Egmore, Tamil Nadu, India

3 DM (Medical Oncology), Head of the Department, Department of Medical Oncology, Institute of Obstetrics and Gynaecology, Egmore, Tamil Nadu, India

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Gayathri R Nair

Senior Resident, Department of Medical Oncology, Institute of Obstetrics and Gynaecology, Egmore, Tamil Nadu,

India

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Article ID: 101421Z01GN2023

doi: 10.5348/101421Z01GN2023CR

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How to cite this article

Nair GR, Jennifer V, Latha KVS. The evaluation, diagnosis, and treatment of malignant mixed Müllerian tumor of the cervix: A case report. Int J Case Rep Images 2023;14(2):110–114.

ABSTRACT


Introduction: Cervical cancer is the most common gynecologic malignancy in India, the most common histology being squamous cell carcinoma. Malignant mixed Müllerian tumor of the cervix, also referred to as carcinosarcoma of the cervix is an unusual entity. Hence, there is a dearth of literature on evaluation and management of such tumors, which is also reflected in the fact that there are no specific consensus guidelines on the same. We present the case of a 35-year-old woman who was diagnosed to have malignant mixed Müllerian tumor of the cervix.

Case Report: Carcinosarcoma cervix is a rare entity, with postmenopausal women being more commonly affected. This makes our case a very unique one, as our patient is a premenopausal, 35-year-old young woman who presented with abnormal uterine bleeding and was subsequently diagnosed to have carcinosarcoma of the cervix. The clinical presentation and management of the case have been discussed.

Conclusion: Malignant mixed Müllerian tumor is an aggressive and rare tumor which can affect the uterus, ovaries, or the cervix. A negative biopsy may not help to rule out the diagnosis of the same. Multimodality treatment including surgical intervention, chemotherapy with paclitaxel and carboplatin, and radiotherapy could benefit this subset of patients.

Keywords: Carcinosarcoma, Cervical cancer, Gynecologic malignancies, Malignant mixed Müllerian tumor

SUPPORTING INFORMATION


Author Contributions

Gayathri R Nair - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

V Jennifer - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

KVS Latha - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Guarantor of Submission

The corresponding author is the guarantor of submission.

Source of Support

None

Consent Statement

Written informed consent was obtained from the patient for publication of this article.

Data Availability

All relevant data are within the paper and its Supporting Information files.

Conflict of Interest

Authors declare no conflict of interest.

Copyright

© 2023 Gayathri R Nair et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.