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Case Series
Guillain–Barré syndrome post stroke: Two case reports
1 Interventional Neurology and Neuro Critical Care, Axon Stroke and Spine Center, Addis Ababa, Ethiopia
2 Internal Medicine, Axon Stroke and Spine Center, Addis Ababa, Ethiopia
3 Neurology and Neurosurgery, Axon Stroke and Spine Center, Addis Ababa, Ethiopia
4 General practitioner, Axon Stroke and Spine Center, Addis Ababa, Ethiopia
Address correspondence to:
Tariku Assefa Soboka
Interventional Neurology and Neuro Critical Care, Axon Stroke and Spine Center, Addis Ababa,
Ethiopia
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Article ID: 101529Z01TA2026
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How to cite this article
Assefa T, Tekle W, Kebede E, Tsehayeneh F, Tirsit E, Ethiopia B, Wudeneh Y. Guillain–Barré syndrome post stroke: Two case reports. Int J Case Rep Images 2026;17(1):7–11.ABSTRACT
Guillain–Barré syndrome (GBS) is the most common and most severe acute paralytic neuropathy. There are different variants of GBS with distinct clinical and pathological features. Most GBS cases are preceded by infection or other immune stimulation that induces an aberrant autoimmune response targeting peripheral nerves and their spinal roots. Molecular mimicry between microbial and nerve antigens is clearly a major driving force behind the development of the disorder, at least in the case of Campylobacter jejuni infection. Some patients have been developing GBS either following or concomitant with head trauma, neurosurgical procedures, and rarely following stroke. The exact mechanism is not well understood probably blood–brain barrier damage may play an essential role in triggering the autoimmune activation that leads to post-stroke GBS.
Keywords: Blood–brain barrier, Campylobacter jejuni, Guillain–Barré syndrome, Post-stroke GBS
SUPPORTING INFORMATION
Author Contributions
Tariku Assefa Soboka - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Final approval of the version to be published
Wonwossen Tekle - Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Eskedar Kebede - Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Fikru Tsehayeneh - Acquisition of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Ebenezer Tirsit - Acquisition of data, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Bereket Ethiopia - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Yonatan Wudeneh - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2026 Tariku Assefa et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
