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Case Report
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| Successive spontaneous abortions caused by a whole-arm translocation between chromosome 10 homologs | ||||||
| Hana Kathryn Cobb1, Dana Knutzen2, Alvin Yuhico Tiu3 | ||||||
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1BS, Fourth Year Medical Student, University of Washington School of Medicine, Seattle, Washington, United States.
2CGC, Certified Genetic Counselor, CHI Franciscan Health, Tacoma, Washington, United States. 3MD, Attending Physician, Internal Medicine, VA Puget Sound Health Care System, Seattle, Washington, United States. | ||||||
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| How to cite this article |
| Cobb HK, Knutzen D, Tiu AY. Successive spontaneous abortions caused by a whole-arm translocation between chromosome 10 homologs. Int J Case Rep Images 2017;8(2):112–115. |
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Abstract
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Introduction:
Whole-arm translocations between homologous chromosomes are rare genetic events that generally involve Robertsonian translocations between acrocentric chromosomes. These inter-homologous translocations only produce unbalanced zygotes, therefore never result in viable pregnancies. The only reports of whole-arm translocations between non-acrocentric homologs involve chromosomes 2, 4, 7 and 9.
Case Report: We report a 21-year-old healthy female with isochromosomes for the short and long arm of chromosome 10 who was ascertained due to successive spontaneous abortions. Genetic testing of decidual tissue and the patient's peripheral blood revealed a whole-arm translocation between the chromosome 10 homologs: 46, XX, t(10;10)(p10;p10). The result of this translocation was two isochromosomes: i(10p) and i(10q). Conclusion: This is the first reported case of a whole-arm translocation between chromosome 10 homologs and is a unique case of successive spontaneous abortions. Our case expands the limited spectrum of whole-arm translocations between non-acrocentric homologous chromosomes. | |
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Keywords:
Isochromosome, Spontaneous abortion, Whole-arm translocation
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Author Contributions
Hana Kathryn Cobb – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Alvin Yuhico Tiu – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Dana Knutzen – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2017 Hana Kathryn Cobb et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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