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Case Report
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| Vancomycin-induced bullous dermatosis | ||||||
| Martin Minwoo Kim1, Katherine Baquerizo1, Pranay Srivastava1, Deepthi Lankalapalli1, Asmat Ullah1 | ||||||
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1Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554 (516) 572-0123, Division of Internal Medicine.
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| How to cite this article |
| Kim MM, Baquerizo K, Srivastava P, Lankalapalli D, Ullah A. Vancomycin-induced bullous dermatosis. Int J Case Rep Images 2016;7(7):476–480. |
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Abstract
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Introduction:
Linear IgA bullous dermatosis (LABD) is a rare mucocutaneous immune mediated blistering skin disease seen in various countries that have ranged from less than 0.5 to 2.3 cases per million individuals per year. The presentation can be similar to other bullous dermatoses, yet it has distinctive clinicopathologic and immunologic features that allow prompt recognition and treatment with complete resolution.
Case Report: A 54-year-old obese Caucasian male with past medical history of atrial fibrillation on warfarin, hypertension, gastroesophageal reflux disease, benign prostatic hyperplasia, and dyslipidemia presented to the emergency department complaining of a generalized blistering rash that initially surrounded the genitalia a week after being discharged from the hospital following a mechanical fall. All medications were reviewed and skin biopsy was taken. He developed the drug-induced variant of LABD to vancomycin with mucosal involvement and compare the resemblance to other autoimmune blistering diseases such as toxic epidermal necrolysis (TEN) and Stevens–Johnson syndrome. This case demonstrates complete resolution of the disease with prompt identification of the underlying disease process based on the clinical and immunohistochemistry findings. Conclusion: Linear IgA bullous dermatosis can be difficult to diagnose as it presents similar to other bullous dermatoses. The problem of differential diagnosis coupled with clinicopathologic and immunologic features of LABD are emphasized to recognize this distinct disease. | |
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Keywords:
Bullous, Vancomycin, Dermatosis, Linear IgA, Nikolsky's sign
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Author Contributions
Martin Minwoo Kim – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Katherine Baquerizo – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Pranay Srivastava – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Deepthi Lankalapalli – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Asmat Ullah – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2016 Martin Minwoo Kim et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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