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Case Report
 
A case of acute megakaryocytic leukemia associated with a nonseminomatous primary mediastinal germ cell tumor diagnosed through elevation of serum lactate dehydrogenase
Emi Noguchi1, Yasushi Omuro2, Yoshiharu Maeda3, Tsuneo Sasaki4
1Department of Medical and Breast Oncology, National Cancer Center Hospital, Tokyo, Japan.
2Department of Chemotherapy, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
3Director, Department of Chemotherapy, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
4Honorary Director, Department of Chemotherapy, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japa.

doi:10.5348/ijcri-2015117-CR-10578

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Emi Noguchi
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How to cite this article
Noguchi E, Omuro Y, Maeda Y, Sasaki T. A case of acute megakaryocytic leukemia associated with a nonseminomatous primary mediastinal germ cell tumor diagnosed through elevation of serum lactate dehydrogenase. Int J Case Rep Images 2015;6(11):720–723.


Abstract
Introduction: Hematologic malignancies are seen in a small percentage of patients with primary mediastinal germ cell tumors (PMGCT).
Case Report: A 29-year-old male patient with a nonseminomatous primary mediastinal germ cell tumor was diagnosed with acute megakaryocytic leukemia. Serum lactate dehydrogenase (LDH) elevation was a diagnostic clue. We discussed our case with a review of literature.
Conclusion: Oncologists should be aware of the association of PMGCT with hematologic malignancies and consider this phenomenon as a differential diagnosis when LDH elevation is present in patients with PMGCT.

Keywords: Primary mediastinal germ cell tumor, Acute megakaryocytic leukemia, Hematologic malignancy, Differential diagnosis


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Author Contributions
Emi Noguchi – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Yasushi Omuro – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Yoshiharu Maeda – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Tsuneo Sasaki – Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Emi Noguchi et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.