Case Report
 
Isolated neurocutaneous peripheral T cell lymphoma, NOS
Talal Hilal
MD, Internal Medicine Resident, University of Kentucky, Lexington, KY, USA

doi:10.5348/ijcri-2014149-CR-10460

Address correspondence to:
Talal Hilal
MD, 900 S. Limestone, 304B Charles T. Wethington Bldg
Lexington, Kentucky
USA 40536
Email: talal.hilal@uky.edu

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How to cite this article
Hilal T. Isolated neurocutaneous peripheral T cell lymphoma NOS. Int J Case Rep Images 2014;5(12):859–863.


Abstract
Introduction: Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of diseases that are a relatively uncommon subtype of non-Hodgkin's lymphoma (NHL) with an overall poor prognosis. They are difficult to classify and targeted therapy does not exist. Patients are usually treated with B cell specific drugs that have not shown to be effective in most subtypes.
Case Report: A 52-year-old male presented with a one-week history of confusion. He was found to have diffuse subcutaneous lumps on his extremities, back, and thorax, and a large swelling over his left face. Imaging revealed a right frontal lobe mass. Biopsy of the mass confirmed PTCL. Further histopathological analysis and imaging for staging diagnosed the subtype as not otherwise specified (NOS). The patient received radiation therapy to the brain followed by systemic chemotherapy with cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP). He responded by the end of the first cycle, but his long-term clinical course remains to be seen.
Conclusion: Treatment for PTCL is a realm requiring further research with efforts focusing on the development of T cell specific drugs.

Keywords: B-cell lymphoma, Lymphoma, Non-Hodgkin lymphoma, Peripheral T cell lymphoma


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Author Contributions
Talal Hilal – Acquisition of data, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published
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The corresponding author is the guarantor of submission.
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Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2014 Talal Hilal. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.

About The Authors

Talal Hilal is Resident in the Department of Internal Medicine at the University of Kentucky in the United States. He earned his medical degree in the form of MB BCh BAO from the Royal College of Surgeons in Ireland (RCSI) in Bahrain where he lived prior to his residency training. His academic interests include general internal medicine, hematology and oncology. He is interested in medical education and has an active leadership role in the residency program. He intends to pursue a fellowship in hematology and oncology and establish a career in academic medicine. Email: talal.hilal@uky.edu