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Case Report
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| Unusual imaging of pancreatic metastasis: A case report of tumor-to-tumor metastasis | ||||||
| Rossella Graziani1, Paola Spaggiari4, Silvia Carrara2, Giovanna Lo Bue1, Alessandro Zerbi3, Luca Balzarini1 | ||||||
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1MD, Department of Radiology, Humanitas Clinical Reserch Hospital, Rozzano (Milan), Italy.
2MD, Department of Gastroenterology and Digestive Endoscopy, Humanitas Clinical Reserch Hospital, Rozzano (Milan), Italy. 3MD, Department of Surgery, Humanitas Clinical Reserch Hospital, Rozzano (Milan), Italy. 4Department of Pathology, Clinical Reserch Hospital, Rozzano (Milan), Italy. | ||||||
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| How to cite this article |
| Graziani R, Spaggiari P, Carrara S, Lo Bue G, Zerbi A, Balzarini L. Unusual imaging of pancreatic metastasis: A case report of tumor-to-tumor metastasis. Int J Case Rep Images 2014;5(11):766–771. |
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Abstract
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Introduction:
Metastasis of one tumor to another tumor is a very rare and controversial phenomenon. Solitary renal cell carcinoma metastasis to a preexisting pancreatic endocrine tumor is distinctly uncommon. We report atypical imaging findings of pancreatic metastasis from renal cell carcinoma, due to tumor-to- tumor metastasis for presence of renal cell carcinoma metastasizing to a pancreatic endocrine tumor.
Case Report: A 78-year-old male suffering from mild anemia underwent to multidetector computed tomography scan showing renal cell carcinoma and solid-cystic pancreatic mass, both resectable, treated with right radical nephrectomy and spleno-distal pancreatectomy. Histopathology of the resected renal and pancreatic specimens confirmed a clear cells right renal cell carcinoma metastatic to endocrine neoplasm of pancreatic body-tail. We compared multidetector computed tomography scan findings and histopathological pancreatic specimen. The imaging finding of peripheral rim enhancement coincided in pancreatic pathologic specimen with presence of pancreatic endocrine tumor. The imaging finding of solid trabeculae inside the mass corresponded in pancreatic pathologic specimen to presence of pancreatic endocrine tumor mixed with lobules of typical renal carcinoma metastatic cells. Finally, the imaging finding of hypoenhancing central area of lesion coincided in pancreatic pathologic specimen with presence of large necrotic component. Conclusion: We describe an unusual multidetector computed tomography scan finding of renal cell carcinoma metastasizing to pancreatic endocrine tumor and emphasize the knowledge of rare phenomena of tumor-to-tumor metastasis. | |
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Keywords:
Tumor-to-tumor metastasis, Pancreatic Endocrine Tumor, Renal cell carcinoma, Pancreatic metastasis
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Author Contributions
Rossella Graziani – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Paola Spaggiari – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Silvia Carrara – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Giovanna Lo Bue – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Alessandro Zerbi – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Luca Balzarini – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2014 Rossella Graziani et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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