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Case Report
 
Alobar holoprosencephaly with unfused thalami: A rare variety of holoprosencephaly
Abubakar A.1, Ibrahim S.M.2, Ahidjo A.1, Tahir A.1
1Department of Radiology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
2Department of Obstetrics and Gynecology University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.

doi:10.5348/ijcri-2014131-CR-10442

Address correspondence to:
Dr. Sanusi Mohammed Ibrahim
Department of Obstetrics and Gynecology, University of Maiduguri Teaching Hospital
PMB 1414, Maiduguri
Nigeria
Phone: +2347066626404
Email: ozovehesan@yahoo.co.uk

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How to cite this article
Abubakar A, Ibrahim SM, Ahidjo A, Tahir A. Alobar holoprosencephaly with unfused thalami: A rare variety of holoprosencephaly. Int J Case Rep Images 2014;5(11):756–760.


Abstract
Introduction: Holoprosencephaly with unfused thalami is a rare malformation involving the forebrain and the face. The epidemiology of the disease is poorly known due to paucity of population based studies.
Case Report: A 32-year-old grand multipara at 27th week gestation found on routine ultrasound examination to have a single live fetus with the fetal head showing dilated single cerebral ventricle, with no evidence of anterior midline echo (falx, inter hemispheric cistern and septum pellucidum). The thalami appear relatively small but not fused with a thin midline linear echoic septum separating them. Two subsequent sonograms at 30th and 33rd weeks of pregnancy, including coronal sonograms of the fetal head, correctly identified a dilated single cerebral ventricle. There was no history of diabetes mellitus, hypertension or previously affected child. Pregnancy termination was done on the couple's request, because of the poor fetal prognosis. Postmortem clinical examination revealed a female newborn with normal body structure. The couple declined consent for autopsy.
Conclusion: Alobar holoprosencephaly with unfused thalami is a rare and severe variety of holoprosencephaly with poorly understood aetiology and poor prognosis.

Keywords: Alobar holoprosencephaly, Unfused thalami, Pregnancy termination


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Author Contributions
Abubakar A. – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ibrahim S.M. – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Ahidjo A. – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Tahir A. – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
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The corresponding author is the guarantor of submission.
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None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2014 Abubakar A. et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



About The Authors

Abubakar A. is specialist registrar in the Department of Radiology of the University of Maiduguri Teaching Hospital, Nigeria. He earned MBBS degree from the University of Maiduguri, and Postgraduate degree (FMCR) from faculty of Radiology of the National Postgraduate Medical College of Nigeria.



Ibrahim Sanusi Mohammed is Lecturer in the College of Medical Sciences, University, and a consultant obstetrician and gynecologist at the University of Maiduguri Teaching Hospital, Maiduguri Nigeria. He earned undergraduate degree (MBBS) from the University of Jos Nigeria and postgraduate degree (FMCOG) from the faculty of Obstetrics and Gynaecology of the National Postgraduate Medical College of Nigeria. He has published over 16 research papers in national and international academic journals and co-authored 2 books. His research interests include infertility, reproductive endocrinology and feto-maternal medicine. He intends to pursue additional research degree in tubal infertility in future. Email: ozovehesan@yahoo.co.uk



Ahidjo A. is a professor of Radiology and an expert in diagnostic and interventional radiology. He had MBBS from the University of Maiduguri and postgraduate degrees (FWACS; FMCR) from faculty of radiology of the West Africa College of Surgeons and National Postgraduate Medical College of Nigeria. He is presently the deputy provost of college of medical sciences of the University of Maiduguri Teaching Hospital, Maiduguri Nigeria. He is an external examiner to the faculty of radiology of both National Postgraduate Medical College of Nigeria and West African College of Surgeons. He is a prolific writer, and has numerous publications in local and international peer reviewed journals.



Tahir A. is an astute administrator and a renowned professor of radiology of international repute. He had MBBS from the University of Maiduguri and postgraduate degrees (FWACS; FMCR) from faculty of radiology of the West Africa College of Surgeons and National Postgraduate Medical College of Nigeria. He has published numerous papers in local and international peer reviewed journals. He is a mentor and role model to professors, readers and senior academicians and medical doctors. He is an external examiner to the faculty of radiology of both National Postgraduate Medical College of Nigeria and West African College of Surgeons. He is presently the Chief Medical Director of the University of Maiduguri Teaching Hospital.