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Case Report
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| Lupus associated hepatitis in active lupus nephritis patient: A case report | ||||||
| Sham Sunder1, Satyanand Sathi2, Himanshu Mahapatra3, Rajesh J2, Anurag Gupta2, Prabhu K2 | ||||||
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1Professor, Department of Nephrology, PGIMER & Dr. Ram Manohar Lohia Hospital, New Delhi, India.
2DM Student, Department of Nephrology, PGIMER & Dr. Ram Manohar Lohia Hospital, New Delhi, India. 3Associate Professor, Department of Nephrology, PGIMER & Dr. Ram Manohar Lohia Hospital, New Delhi, India. | ||||||
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| How to cite this article |
| Sunder S, Sathi S, Mahapatra H, Rajesh J, Gupta A, Prabhu K. Lupus associated hepatitis in active lupus nephritis patient: A case report. Int J Case Rep Images 2014;5(8):581–585. |
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Abstract
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Introduction:
Systemic lupus erythematosus and autoimmune hepatitis (AIH) both are autoimmune disease causing inflammation of the liver. It is important to differentiate lupus hepatitis from AIH for diagnosis, treatment and prognosis of the disease.
Case Report: Herein, we report a case of a 17-year-old female with a two-year history of multiple joint pain, six-month history of swelling, rash, mouth ulcers and a 15-day history of jaundice. An investigation revealed positive antinuclear antibody, positive anti-DsDNA, low serum C3, C4, very high serum bilirubin, high SGOT/SGPT and nephrotic range proteinuria. Antibody tests for autoimmune hepatitis were negative. Renal biopsy showed focal proliferative lupus nephritis. Liver biopsy was suggestive of lupus-hepatitis. Jaundice responded to steroid therapy dramatically. Conclusion: Lupus associated hepatic disease must be differentiated from hepatitis caused by drugs, toxins, viral and other autoimmune diseases. Liver histology may be necessary to confirm a diagnosis. | |
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Keywords:
Lupus nephritis, Lupus associated hepatitis, Autoimmune hepatitis
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Author Contributions
Sham Sunder – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Satyanand Sathi – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Himanshu Mahapatra – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published Rajesh J – Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published Anurag Gupta – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published Prabhu K – Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2014 Sham Sunder et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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