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Case Report
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| A rare association of polyglandular autoimmune endocrinopathy type II with hypoparathyroidism | ||||||
| Manish Gutch1, Sukriti Kumar2, Syed Mohd Razi1, Sanjay Saran1, Keshav Kumar Gupta2 | ||||||
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1MD, Senior Resident, Dept of Endocrinology, L.L.R.M Medical College Meerut, UP, India.
2MBBS, Junior Resisdent, Department of Radiodiagnosis, S.G.P.G.I, Lucknow, UP, India. 3DM, Prof. & Head, Dept of Endocrinology, L.L.R.M Medical College Meerut, UP, India. | ||||||
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| How to cite this article |
| Gutch M, Kumar S, Razi SM, Saran S, Gupta KK. A rare association of polyglandular autoimmune endocrinopathy type II with hypoparathyroidism. Int J Case Rep Images 2014;5(8):542–545. |
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Abstract
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Introduction:
Polyglandular autoimmune (PGA) syndromes are uncommon condition characterized by presence of one or more organ-specific autoantibodies directed against specific antigen of organ involved. Polyglandular autoimmune syndrome type II is also known as Schmidt's syndrome and found to be associated with autoimmune Addison's disease with autoimmune thyroid diseases and/or type 1 diabetes mellitus.
Case Report: A previously diagnosed primary hypothyroid 35-year-old female admitted with a 15-day history of general malaise. She complained of polyuria, polydipsia, weight loss, abdominal pain and vomiting. She was diagnosed diabetic ketoacidosis due to previously undiagnosed type I diabetes (capillary blood glucose >500mg/dL, pH 7.20) and intravenous fluids and intravenous insulin infusion was started. After four hours, despite of appropriate fluid resuscitation and normalization of blood glucose, her condition had deteriorated, she became more tachycardic and hypotensive. At this time, the patient was reassessed and a short Synacthen test was carried out then hydrocortisone was administered immediately after the short Synacthen test. Test result showed hypocortisolemia (Addison's disease). During the course of hospital stay she developed tetany then on further investigations hypoparathyroidism was also diagnosed. Herein, we report a rare case of report Ppolyglandular autoimmune endocrinopathies type II with simultaneous involvement of parathyroid gland. Conclusion: Patients presented with an autoimmune disease should be screen for other autoimmune conditions as early detection of other organs specific autoantibody may reduce morbidity and mortality associated in patients with autoimmune polyglandular syndrome. | |
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Keywords:
Type II polyglandular autoimmune syndrome, Diabetes, Schmidt's syndrome, Addison's disease, Hypothyroidism, Hypoparathyroidism
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Author Contributions
Manish Gutch – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Sukriti Kumar – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Syed Mohd Razi – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Sanjay Saran – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Keshav Kumar Gupta – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2014 Manish Gutch et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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