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Case Series
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| Granular tumors of the central nervous system: A case series | ||||||
| Janese Trimaldi1, Nicole D Riddle2, Jeremy W Bowers3, Harry R van Loveren4, Kondi Wong1 | ||||||
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1Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, FL, USA.
2Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA. 3Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA. 4Department of Neurosurgery, University of South Florida College of Medicine, Tampa, FL, USA. | ||||||
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| How to cite this article: |
| Trimaldi J, Riddle ND, Bowers JW, Loveren HRv, Wong K. Granular tumors of the central nervous system: A case series. International Journal of Case Reports and Images 2013;4(1):1–6. |
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Abstract
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Introduction:
Granular cell tumors of the central nervous system are rare tumors. To date, eight cases arising from cranial nerves have been reported. Granular cell tumors have also been found arising from the neurohypophysis and its stalk. Due to their rarity and histological similarity to other central nervous system (CNS) tumors with a granular appearance, they often pose a diagnostic conundrum. The differential diagnosis is surprisingly diverse and includes granular cell astrocytoma, infundibular granular cell tumor, spindle cell oncocytoma of the adenohypophysis, granular and oncocytic variants of pituitary adenoma, meningioma, pituicytoma and intrasellar schwannoma. Distinguishing between the CNS tumors with granular features is important because some tumors have an increased recurrence risk or a poor prognosis.
Case Report: To highlight the histological features of granular lesions of the central nervous system, including the immunohistochemical profile and electron microscopic depiction, we review two cases each with a similar granular histology and a different final diagnosis. Conclusion: Thorough online literature search revealed several cases of granular cell lesions of the CNS, however, oftentimes the diagnosis is difficult to come by and the differential is long. Conclusion: Granular cell tumor and its variants, though uncommon, must be included in the differential diagnosis of CNS lesions. | |
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Key Words:
Granular, Tumors, Central nervous system (CNS)
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Author Contributions:
Janese Trimaldi – Conception and design, Acquisition of data, Drafting the article, Final approval of the version to be published Nicole D Riddle – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published Jeremy Bowers – Conception and design, Acquisition of data, Critical revision of the article, Final approval of the version to be published Harry Van Loveren – Acquisition of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Kondi Wong – Conception and design, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
Authors declare no conflict of interest. |
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Copyright:
© Janese Trimaldi et al. 2013; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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