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Case Report
 
Situs inversus and metastatic renal cell carcinoma: A case report
Sunil Rangarajan1, Bhuvana Sunil2, Arun S Shet3
1Junior Resident, Department of Medical Oncology, St. John's Medical College and Hospital, Bangalore, Karnataka, India.
2Research Associate, St. John's Research Institute, Bangalore, Karnataka, India.
3Professor & Head, Department of Medical Oncology, St. John's Medical College and Hospital, Bangalore, Karnataka, India.

doi:10.5348/ijcri-2012-11-208-CR-1

Address correspondence to:
Arun S Shet
Department of Medical Oncology, St. John's Medical College and Hospital
The St. John's National Academy of Health Sciences, Sarjapur Road
Bangalore 560034
India
Phone: 91-80-22065744
Fax: 91-80-25532037
Email: arunshet1@gmail.com

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How to cite this article:
Rangarajan S, Sunil B, Shet AS. Situs inversus and metastatic renal cell carcinoma: A case report. International Journal of Case Reports and Images 2012;3(11):1–4.


Abstract
Introduction: Situs Inversus Totalis is a rare congenital condition with an autosomal recessive inheritance. Most of the people with SIT are asymptomatic, making its diagnosis a challenge. Although many cases of cancers co-existing with SIT have been reported in medical literature, the co-existence of RCC with SIT is extremely rare. We are presenting the 5th reported case in the published medical literature.
Case Report: We report a case of a 65- year-old male who was presented with intractable back pain, difficulty in performing daily activities and unintentional weight loss. Evaluation of these symptoms revealed SIT, a right renal mass and widespread metastatic deposits. Immunohistochemical analysis confirmed the diagnosis of clear cell type of renal cell carcinoma.
Conclusion: Situs Inversus is a rare congenital abnormality which may be associated with renal anomalies, Kartagener syndrome, and several types of malignancies. Further study is needed to characterize the genetic basis of SI and establish whether there is a causal basis between SI and the development of malignancy or not.

Key Words: Situs inversus totalis, Renal cell carcinoma, Malignancy


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Author Contributions:
Sunil Rangarajan – Conception, design, and acquisition of data, Drafting of the article, Final approval of the version to be published
Bhuvana Sunil – Conception, design, and acquisition of data, Drafting of the article, Final approval of the version to be published
Arun S Shet – Conception and design, Critical revision of the article, Final approval of the version to be published
Guarantor of submission:
The corresponding author is the guarantor of submission.
Source of support:
None
Conflict of interest:
Authors declare no conflict of interest.
Copyright:
© Sunil Rangarajan et al. 2012; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.)