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Case Report
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| Recurrent intestinal type sinonasal adenocarcinoma treated with FOLFOX6 chemotherapy: Case report and review of literature |
| Mateya E Trinkaus1, Andrew Coleman2, Ieta D'Costa2, Elizabeth Sigston3, Danny Rischin1 |
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1Peter MacCallum Cancer Centre, Department of Medical Oncology, East Melbourne, Victoria, Australia.
2Peter MacCallum Cancer Centre, Department of Radiation Oncology, East Melbourne, Victoria, Australia. 3Monash Medical Centre, Department of Otolaryngology, Head and Neck Surgery, East Bentleigh, Victoria, Australia. |
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doi:10.5348/ijcri-2012-08-158-CR-5
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Address correspondence to: Danny Rischin Peter MacCallum Cancer Centre, Department of Medical Oncology Locked Bag No. 1, A Beckett St. East Melbourne, VIC 8006 Australia Phone: 011 (03) 9656 1804; Fax: 011 (03) 9656 1408 Email: danny.rischin@petermac.org |
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| How to cite this article: |
| Trinkaus ME, Coleman A, D'Costa I, Sigston E, Rischin D. Recurrent intestinal type sinonasal adenocarcinoma treated with FOLFOX6 chemotherapy: Case report and review of literature. International Journal of Case Reports and Images 2012;3(8):17–20. |
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Abstract
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Introduction:
Sinonasal intestinal-type adenocarcinoma is a rare malignancy originating most commonly from the ethmoid sinuses. Morphologically, this cancer tends to resemble intestinal adenocarcinoma with immunohistologic staining mirroring what would be expected for a gastrointestinal malignancy. Definitive treatment involves surgical resection often followed by radiation. In the inoperable or metastatic setting, there is limited evidence for effective chemotherapeutic regimens.
Case Report: A patient with unresectable sinonasal intestinal-type adenocarcinoma. Chemotherapy with 5-FU and oxaliplatin (FOLFOX) was initiated based on the rationale of similar morphology and immunohistochemistry (IHC) of this patient's sinonasal intestinal-type adenocarcinoma and colon adenocarcinoma and the affirmed efficacy of FOLFOX regimens in the metastatic and adjuvant colon cancer settings. The patient had a dramatic partial radiologic response by response evaluation criteria in solid tumors (RECIST) criteria. Conclusion: Intestinal-type sinonasal adenocarcinoma presents a rare and challenging opportunity to select active chemotherapy for unresectable disease. We propose that further investigation of colorectal chemotherapy regimens including FOLFOX in intestinal-type sinonasal adenocarcinoma is warranted. | |
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Key Words:
Sinonasal adenocarcinoma, Intestinal-type, Oxaliplatin, Treatment
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Author Contributions:
Mateya E Trinkaus – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Andrew Coleman – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Ieta D'Costa – Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Elizabeth Sigston – Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published Danny Rischin – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
Authors declare no conflict of interest. |
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Copyright:
© Mateya E Trinkaus et al. 2012; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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