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Case Report
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| Primary hyperparathyroidism presenting as paraneoplastic syndrome in a patient with renal cell carcinoma |
| Hannah Winter1, Melanie Field1, James McDaid1, Deepak Vishwanath1, Nicholas Inston1 |
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1Renal Surgery Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TT.
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doi:10.5348/ijcri-2012-4-108-CR-5
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Address correspondence to: Miss Hannah Winter 48 West Street, Stourbridge West Midlands, DY8 1XN UK Phone: 07817765002, 01384361081 Email: hwinter@doctors.org.uk |
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| How to cite this article: |
| Winter H, Field M, McDaid J, Vishwanath D, Inston N. Primary hyperparathyroidism presenting as paraneoplastic syndrome in a patient with renal cell carcinoma. International Journal of Case Reports and Images 2012;3(4):19–22. |
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Abstract
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Introduction:
Hypercalcaemia in the presence of malignancy is commonly attributed to paraneoplastic phenomenon, particularly when associated with renal cell carcinoma. However, other causes of hypercalcaemia should be sought which can be more easily treated.
Case Report: We report a case of a 54-year-old man presenting with resistant hypercalcaemia with an underlying diagnosis of renal cell carcinoma with brain metastases requiring multiple admissions for intravenous rehydration and bisphosphonates. On further investigation and surgical exploration, a parathyroid adenoma was identified, removed and confirmed on histology. His symptoms settled and biochemistry normalised, improving quality of life and reducing hospital admissions. Conclusion: This case emphasises the importance of considering primary hyperparathyroidism as a cause of hypercalcaemia in the presence of malignancy. Surgery for primary hyperparathyroidism can offer curative treatment and enhance quality of life in a palliative patient. | |
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Key Words:
Hypercalcaemia, Parathyroid adenoma, Paraneoplastic, Renal cell carcinoma
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Author Contributions:
Hannah Winter - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Melanie Field - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published James McDaid - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Deepak Vishwanath - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Nicholas Inston - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
Authors declare no conflict of interest. |
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Copyright:
© Hannah Winter et. al. 2012; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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