Introduction: Multiple myeloma is characterized by plasma cell infiltration of the bone marrow and presence of a monoclonal protein in plasma and/or the urine. Multiple myeloma with biclonal gammopathy is rare (1%).
Case Report: In this report, we describe a case of biclonal multiple myeloma having two M bands on serum protein electrophoresis. He had elevated serum IgG and IgA levels. Ig G and IgA with Kappa and Lambda light chains respectively were detected by immunofixation. It is a very rare immunofixation pattern seen in any gammopathy. The patient presented with vertebral and pelvic bone involvement and neurosensory involvement of both the lower limbs. Patient has been lost for follow up at present.
Conclusion: It is a very rare form of multiple myeloma accounting for 1% of all cases. Clinical presentation and response to therapy in such cases appears to be like any other multiple myeloma cases. They should be treated like any other multiple myeloma case.