Introduction: Because SAPHO is a rare syndrome, its treatment is controversial. We are presenting a case of a patient with SAPHO Syndrome, who was treated with combined drug regimen.

Case Report: A 16-year-old man was admitted to our hospital with hip and back pain for one month. The patient was not able to move his thighs; therefore he could not walk because of pain. He had papullopustular acne on his back and face. Also, the patient had a mild pain on upper chest wall caused by sternoclavicular arthritis. The erytrocyte sedimentation rate was 69 mm/1^hrhour and C-reactive protein was 2.8 mg/dl. HLA B27 was positive. Magnetic resonance imaging of the sacroiliac joint revealed a bilateral symmetrical sacroiliitis. Whole body Tc 99m-MDP bone scintigraphy detected bull's head sign. A diagnosis of SAPHO syndrome was made. The patient was treated with NASIDs, isotretinoin, sulphasalasine, methotrexate, hydroxy-chloroquine and methylprednisolone. Two weeks later, his pain was relieved. Two years later he is still on complete remission.

Conclusion: SAPHO syndrome may be treated with combined drug regimen to obtain complete remission and relieve pain.