Case Series
| ||||||
Giant urinary bladder stones | ||||||
Charles Azuwike Odoemene | ||||||
Senior Lecturer/Consultant Urologist, Urology unit, Department of Surgery, Federal Teaching Hospital Abakaliki (FETHA), Ebonyi State, Nigeria
| ||||||
| ||||||
[HTML Abstract]
[PDF Full Text]
[Print This Article] [Similar articles in PubMed] [Similar articles in Google Scholar] |
How to cite this article |
Odoemene CA. Giant urinary bladder stones. Int J Case Rep Images 2018;9:100933Z01CO2018. |
ABSTRACT
| ||||||
Introduction: Giant urinary bladder stone is one that weighs 100 grams or more and more than four centimeters in diameter. It is a rare occurrence in modern urological practice. Most patients have associated bladder outlet obstruction predisposing to recurrent urinary tract infections (UTI), urinary frequency, urinary incontinence, hematuria, urinary retention. Most giant bladder stones are radiopaque and plain abdominal radiographs will be useful in diagnosis. They preferred form of treatment is open cystolithotomy. Case Series: Three cases of giant urinary bladder stones were encountered in a period of nine years. Two (66.7%) patients had neurogenic bladder and one (33.3%) patient had benign prostatic hyperplasia. The three were symptomatic for more than five years before presenting due to poverty, ignorance and unavailability of health facilities with common imaging techniques. All the patients had open cystolithotomy and did well post operatively. Conclusion: Giant urinary bladder stones is still a rarity in modern urological practice causing enormous morbidity when presentation is late as in the cases in this series. The three stones were radiopaque and open cystolithotomy was safe in extracting the stones completely without damage to the urinary bladder. All the stones were mixed in nature. Keywords: Cystolithotomy, Giant urinary bladder stones, Hematuria, Late presentation | ||||||
INTRODUCTION
| ||||||
Bladder stones account for 44.4% of urinary tract calculi in Nigeria [1], [2], [3]. In the western world, bladder stones account for 5% of urinary tract stones [3], [4], [5], [6], and 1.5% of urologic hospital admissions [7], [8]. The higher proportion of lower urinary tract stone in the developing world has been attributed to increased incidence of urinary tract infections and infestations [3]. Bladder stones are commoner in men than in women with an incidence of 95% [4],[6], [9]. Risk factors that promote bladder stone formation include urinary tract infection by urease producing organisms, chronic urinary retention and bladder outlet obstruction. These conditions are resultant effects of prostatic diseases, bladder diverticulum, genital prolapse in females, neurogenic bladder dysfunction, urethral stricture, foreign body and prolonged urethral catheterization [4],[10]. Vesical calculus is said to be giant when it weighs 100 grams (gm) or more and more than 4 centimetres (cm) in the greatest diameter [3],[5],[6], [11], [12]. The biggest vesical calculus weighed 6294 gm and was reported by Arthure in 1953 and found in a bladder diverticulum [4],[6],[10],[11],[13] . The calculus reported by Randall in 1921 weighed 1914 gm and by Powers and Matfferd in 1952 weighed 1410 gm [13]. Below is my experience in the management of three giant bladder stones encountered over a period of nine years. | ||||||
CASE SERIES
| ||||||
Case 1 His hemoglobin (Hb) was 11.7 gm/dl, total white blood cell count (TWBC) 14,300/mm3, neutrophil count of 86%, erythrocyte sedimentation rate (ESR) of 60 mm/hr, serum urea was 19 mg/dl and creatinine was 1 mg/dl. Urine culture yielded heavy growth of proteus and klebsiella both sensitive to levofloxacin. Abdomino-pelvic ultrasonography (US) showed large stone in the bladder 5.3 cm in diameter, bilateral hydroureter, hydronephrosis and heteroechoic prostate with a volume of 16 cm3. A plain abdominal X-ray and intravenous urography (IVU) showed huge egg shaped stone 7x5 cm at the bladder neck Figure 1 (A and B). Attempt at urethral catheterization failed as the stone occluded the internal meatus. The urinary tract infection (UTI) was treated with parentral levofloxacin. Under general anesthesia, open cystolithotomy, bladder and prostatic biopsies were done. The weighed 512 gms and qualitative analysis using the Uldall, a wet chemical analysis of urinary calculi [14] showed mixed stone comprising calcium (Ca2+), magnesium (Mg2+), ammonium (NH4+), phosphate (PO4-) and carbonate (CO3-) (Figure 2). Bladder mucosa biopsy showed no malignant change while the prostate showed chronic prostatitis. The patient had an artificial sphincter inserted to control the urinary incontinence. Six months after discharge, the patient was very stable with the suprapubic fistulae healed up.
Case 2
Case 3 | ||||||
| ||||||
| ||||||
| ||||||
| ||||||
| ||||||
| ||||||
DISCUSSION | ||||||
Giant urinary bladder calculi are a rare clinical entity in today”s modern urological practice buttressed by the fact that only 30 cases have been reported in the English literature [4], [10],[15], [16] . In this series, three cases were seen in nine years. Cases 1 and 2 had neurogenic bladder dysfunctions from cord injury following spinal anesthesia and uncontrolled diabetes mellitus respectively. The third case had bladder outlet obstruction sequel to prostatic disease and prolonged effect of salbutamol on the detrusor muscle. There was recurrent UTI following urine stasis in the three cases. Klebsiella, E. coli, proteus and pseudomonas were the bacteria cultured. The stones were mixed in nature comprising of Ca2+, Po42, Mg2+, Co3-, NH4+, oxalate, and urate. The chemical composition of the stones in this series is compatible with the colonization status of the urinary tract which plays a role in stone formation. Thus, klebsiella, proteus, pseudomonas, (urease positive organisms) predisposed to magnesium, phosphate, ammonium and carbonate apatite while E. coli was associated with formation of calcium oxalate and urate stones. These observations have been documented by other researchers [6]. Most vesical calculi are composed of triple phosphate, calcium carbonate and calcium oxalate [4], [10],[15]. The constituents of the giant bladder stones in this series are the same. Furthermore, Becher et al. reported a giant vesical uric acid calculus weighing 235gm with a minor component of asymmetrical calcium oxalate [4], [10],[15],[17]. Instances of formation of bladder stone around a foreign body, sutures, or other objects introduced into the bladder have been reported [6],[10],[15]. It is thought that a giant vesical calculus develops from a nidus of the infected material or from a solitary ureteric stone with progressive layer wise deposition of calcified matrix. Thus, earlier stated factors may mutually contribute to the formation of a stone [6],[8],[10],[15], [16]. Furthermore, studies have shown that nucleus of bladder stone does not contain struvite or calcium phosphate but subsequent concentric layer contain large amount of these substances. Schwartz and Stoller noted that infection may not be the inciting factor in stone formation but may play a role in subsequent stone crystallization [5],[8]. Apart from the predisposing factors for vesical calculus outlined above, diet and amount of fluid intake are also important [10],[15], [16]. The common presentation of patients with giant urinary bladder stones includes painful micturition, urinary incontinence,hematuria, pyuria, recurrent UTI, suprapubic pain and urinary retention [4],[8],[10],[13],[15]. These were present in the patients in this series. Those with urinary retention pass urine in supine position as the calculus obstructs the bladder outlet in erect position [4],[15]. Giant vesical calculus can occupy the entire bladder cavity occluding the ureteric orifices causing hydroureter, hydronephrosis, renal failure [4],[6], [10],[13],[15],[18],[19] and rarely bladder rupture [4],[20]. Cases 1 and 2 in this series had bilateral hydroureter and hydronephrosis. Case 2 in addition had renal failure. The three patients in this series were symptomatic for more than five years. Reasons for the late presentation include poverty, ignorance and absence of health centres with simple imaging facilities. This was noted by another researcher from the same geographical location [3]. Plain abdominal X-rays, abdominal US and intravenous urography (IVU) were the imaging modalities used in this study to make diagnosis. Most of the bladder calculi are radiopaque and are diagnosed with plain radiographs. Other imaging modalities include US, IVU, CT – scan, magnetic resonance imaging. However, contrast enhanced CT is the investigation of choice as it is more sensitive in detecting urinary tract stones including uric acid stones [4],[10], [15]. Treatment in all cases was by open surgery and no case of bladder mucosa malignant change was noted in this series. Other modalities of treatment have evolved such as cystolithotripsy for small or moderate calculus and have added advantage for corrective procedure for bladder outlet obstruction [10], [15]. Though open surgery is preferred for large stones [4],[10], [15], spontaneous expulsion of two giant bladder stones by a female patient has been documented [21]. | ||||||
CONCLUSION
| ||||||
Giant bladder stones are rare in modern urological practice as three cases were seen in nine years in this series. Furthermore, most of the cases in the literature are case reports. Poverty, ignorance, lack of health centres with simple diagnostic facilities and specialist consultation were responsible for late presentation and enormous morbidity in this series. Finally in-spite of the many years of sustained vesical obstruction, one patient surprisingly had renal failure. | ||||||
REFERENCES
| ||||||
|
[HTML Abstract]
[PDF Full Text]
|
Acknowledgements
I sincerely thank Stanley Ndoh for his technical assistance. |
Author Contributions
Charles Azuwike Odoemene – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
Guarantor of Submission
The corresponding author is the guarantor of submission. |
Source of Support
None |
Consent Statement
Written informed consent was obtained from the patient for publication of this case series. |
Conflict of Interest
Author declares no conflict of interest. |
Copyright
© 2018 Charles Azuwike Odoemene. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
|