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Case Report
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| Macroglossia and periorbital ecchymoses in a patient with systemic amyloidosis: A case report | ||||||
| Jamille Hemétrio Salles Martins Costa1, Aloísio Benvindo de Paula2, Leonardo de Oliveira Campos3, Rafaela Brito de Paula4, Daniel Riani Gotardelo5 | ||||||
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1Internal Medicine Resident, Hospital Márcio Cunha/FSFX; Ipatinga, MG, Brazil.
2Infectologist, Internal Medicine Residency Program Coordinator, Hospital Márcio Cunha/FSFX; Ipatinga, MG, Brazil. 3Neurologist, Hospital Márcio Cunha/FSFX; Ipatinga, MG, Brazil. 4Medical Student, Universidade Federal de Uberlândia; Uberlândia, MG, Brazil. 5Associate Professor, School of Medicine, Vale do Aço/Instituto Metropolitano de Ensino Superior; Ipatinga, MG, Brazil. | ||||||
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| How to cite this article |
| Costa JHSM, de Paula AB, de Oliveira Campos L, de Paula RB, Gotardelo DR. Macroglossia and periorbital ecchymoses in a patient with systemic amyloidosis: A case report. Int J Case Rep Images 2015;6(6):343–347. |
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Abstract
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Introduction:
Amyloidoses comprise a group of rare diseases associated with the extracellular deposition of misfolded proteins, which can compromise the function of target organs and give rise to clinical disease with a broad range of manifestations. The aim of this study was to report a case of systemic amyloidosis with macroglossia and periorbital ecchymoses - two uncommon semiological findings.
Case Report: A 59-year-old female presented with dyspnea, vomiting, abdominal pain and distension. The patient was admitted for diagnostic workup, during which malnutrition, infiltrative thickening of the suprapubic abdominal wall, anasarca, macroglossia, and tongue petechiae were identified. The clinical picture was compounded by hematochezia and periorbital ecchymoses during hospitalization. Biopsy of the dermis and subcutaneous tissue of the hypogastrium revealed amorphous eosinophilic extracellular depositions on Congo red staining which had green birefringence under polarized light microscopy, consistent with amyloidosis. Conclusion: Patients with amyloidosis are usually extensively investigated before a diagnosis is made because in addition to being a rare disease with multifaceted presentation features, the signs and symptoms of amyloidosis are nonspecific. In the present report, cutaneous thickening with formation of periorbital ecchymoses accompanied by macroglossia were suggestive of amyloidosis, whose treatment and prognosis are influenced by timely diagnosis. | |
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Keywords:
Amyloidosis, Macroglossia, Periorbital ecchymoses
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Author Contributions
Jamille Hemétrio Salles Martins Costa – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Aloísio Benvindo de Paula – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Leonardo de Oliveira Campos – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Rafaela Brito de Paula – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Daniel Riani Gotardelo – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2015 Jamille Hemétrio Salles Martins Costa et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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About The Authors
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