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Case Series
Antibodies everywhere: The spectrum of IgG4-related disease—A case series and literature review
1 Resident, Internal Medicine, Henry Ford Allegiance, Jackson, Michigan, USA
2 Medical Student, GMC, Amritsar, Punjab, USA
3 Hospitalist, Internal Medicine, Henry Ford Allegiance, Jackson, Michigan, USA
Address correspondence to:
Bipneet Singh
159 W Michigan Avenue, Jackson, Michigan 49201,
USA
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Article ID: 101511Z01BS2025
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How to cite this article
Singh B, Grover P, El-Feki I, Ethakota J, Kaur G, Malik M. Antibodies everywhere: The spectrum of IgG4-related disease—A case series and literature review. Int J Case Rep Images 2025;16(1):121–128.ABSTRACT
Introduction: IgG4-related disease (RD) is now known to affect multiple organs, including the gastrointestinal system, kidneys, lungs, and retroperitoneum. Diagnosis of IgG4-RD involves a combination of clinical, radiological, serological, and histopathological findings.
Case Series: This case series underscores the importance of recognizing IgG4-RD as a potential etiology of diseases of unclear pathology with patient presentations, including pancreatitis, cholangitis, renal and mesenteric ischemia, back mass, and interstitial lung disease.
Conclusion: Further, we discuss the histological findings, imaging, serology, other organ involvement and response therapy (HISORt) criterion of diagnosis, and treatment options including steroid-sparing agents.
Keywords: Autoimmune pancreatitis, HISORt criterion, IgG4 pancreatitis, Rituximab, Sclerosing cholangitis
SUPPORTING INFORMATION
Author Contributions
Bipneet Singh - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Drafting the article, Final approval of the version to be published
Palak Grover - Interpretation of data, Drafting the article, Final approval of the version to be published
Iman El-Feki - Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Jahnavi Ethakota - Revising it critically for important intellectual content, Final approval of the version to be published
Gurleen Kaur - Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mandeep Malik - Interpretation of data, Drafting the article, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Bipneet Singh et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
