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Case Report
Erythema multiforme: A case report with oral manifestations
1 University of Taubaté – UNITAU, Taubaté, São Paulo, Brazil
2 Educational University of Santa Catarina, Joinville- SC, Brazil
3 CK Estomatologia, São Paulo, SP 04531-012, Brazil
4 Centro Universitário Braz Cubas
Address correspondence to:
Luis Felipe das Chagas e Silva de Carvalh
Visconde do Rio Branco, 210, Centro, Curitiba, PR 80420210,
Brazil
Message to Corresponding Author
Article ID: 101328Z01GM2022
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How to cite this article
de Carvalho LFCS, Monteiro GR, Máximo G, Coelho MCF, da Silva Peralta F, Kitakawa D. Erythema multiforme: A case report with oral manifestations. Int J Case Rep Images 2022;13(2):61–65.ABSTRACT
Introduction: Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disease, which may be related to herpes simplex virus, use of certain medications, autoimmune disease, radiation, immunization, pregnancy, period, and food additives or chemicals. It is a condition that occurs predominantly in young adults, with a slight female preponderance and no predilection. Clinically, EM presents erosive and erythematous plaques, affecting mainly the lips and oral mucosa, called target lesions, which may progress to vesiculobullous lesions. The aim of this study is to report a case shown as a positive response to treatment.
Case Report: This is a case of EM in a 50-year-old female patient with a persistent ulcer on the lower lip. The clinical presentation showed an ulcerated lesion that extended through the right labial vermilion, semi-mucosa and jugal mucosa, in addition to painful symptoms. Although the diagnostic hypothesis of EM, an incisional biopsy was performed, that confirmed the clinical diagnosis of EM. As treatment, topical use of 0.05% clobetasol propionate for 15 days was prescribed on the lesion. The patient returned in seven days with significant improvement of the site. It was decided to do only the follow-up and not to intervene with systemic corticosteroid therapy. The patient is followed up for 15 months without recurrence of the lesion. The histopathological analysis of this type of lesion is essential for the diagnosis of the lesion. In this way, we can rule out differential diagnoses, especially pemphigus vulgaris and in children, hands, feet, and mouths disease. In this work, it was observed how important the histopathological analysis is necessary in more complex cases, because in this way the therapeutic approach was effective.
Conclusion: The present case report represents how important the histopathological analysis is necessary in more complex cases to conclude the diagnosis, therefore is possible conduce the best choose of treatment for patient.
Keywords: Autoimmune disease, Corticoid therapy, Erythema multiforme, Oral manifestations
SUPPORTING INFORMATION
Author Contributions
Gabriela Reganin Monteiro - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Gabriela Máximo - Substantial contributions to conception and design, Acquisition of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Maria Clara Ferreira Coelho - Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published
Felipe da Silva Peralta - Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published
Dárcio Kitakawa - Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published
Luis Felipe das Chagas e Silva de Carvalh - Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 Gabriela Reganin Monteiro et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
