Case Report


Optic neuritis in post-Covid rhino-orbito-cerebral mucormycosis (ROCM): A rare presentation

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1 DOMS, DNB Ophthalmology, Assistant Professor, Dept. of Ophthalmology, GSVM Medical College and LLR Hospital, Kanpur, U.P., India

2 MS Ophthalmology, Professor and HOD, Dept. of Ophthalmology, GSVM Medical College and LLR Hospital, Kanpur, U.P., India

3 MS, Junior Resident, MS Ophthalmology, GSVM Medical College and LLR Hospital, Kanpur, U.P., India

4 MS Ophthalmology, Assistant Professor, GSVM Medical College and LLR Hospital, Kanpur, U.P., India

5 Senior Resident, MS Ophthalmology, GSVM Medical college and LLR Hospital, Kanpur, U.P., India

6 Junior Resident, MS Ophthalmology, GSVM Medical College and LLR Hospital, Kanpur, U.P., India

Address correspondence to:

Anshika Gupta

Room No- 4, PG Girls Hostel, GSVM Medical College, Kanpur, U.P.,

India

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Article ID: 101256Z01PS2021

doi: 10.5348/101256Z01PS2021CR

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How to cite this article

Singh P, Khan P, Gupta A, Patel N, Chandra T, Yadav DK. Optic neuritis in post-Covid rhino-orbito-cerebral mucormycosis (ROCM): A rare presentation. Int J Case Rep Images 2021;12:101256Z01PS2021.

ABSTRACT


Introduction: Rhino-orbito-cerebral mucormycosis is a devastating opportunistic and fulminant infection. We report an unusual and rare case of optic neuritis as the complication of post-Covid rhino-orbito-cerebral mucormycosis (ROCM).

Case Report: A 37-year-old patient presented with ocular symptoms associated with ROCM and diminution of vision in left eye 14 days post-Covid. Radiological investigation (magnetic resonance imaging, MRI) showed heterogeneous altered signal intensity in left optic nerve. Fundus examination showed characteristic findings of optic neuritis.

Conclusion: In advanced stage of sino-invasive rhino-orbito-cerebral mucormycosis perineural invasion is a proven histological feature. In our case scenario, the optic nerve of the patient got involved through perineural spread of mucormycosis, causing inflammation along the nerve resulting in optic neuritis.

Keywords: Optic neuritis, Perineural invasion, ROCM

SUPPORTING INFORMATION


Author Contributions

Parul Singh - Substantial contributions to conception and design, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published

Perwez Khan - Substantial contributions to conception and design, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published

Anshika Gupta - Acquisition of data, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Namrata Patel - Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published

Tejasvini Chandra - Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Dinesh Kumar Yadav - Acquisition of data, Drafting the article, Final approval of the version to be published

Guarantor of Submission

The corresponding author is the guarantor of submission.

Source of Support

None

Consent Statement

Written informed consent was obtained from the patient for publication of this article.

Data Availability

All relevant data are within the paper and its Supporting Information files.

Conflict of Interest

Authors declare no conflict of interest.

Copyright

© 2021 Parul Singh et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.