 |
Case Report
A rare occurrence of anti-glomerular basement membrane glomerulonephritis complicated by heparin-induced thrombocytopenia
1 Department of Nephrology, Peninsula Health, Frankston, Victoria, Australia
Address correspondence to:
Rebecca Xu
Department of Nephrology, Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199,
Australia
Message to Corresponding Author
Article ID: 101112Z01RX2020
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
Xu R, Dang MH. A rare occurrence of anti-glomerular basement membrane glomerulonephritis complicated by heparin-induced thrombocytopenia. Int J Case Rep Images 2020;11:101112Z01RX2020.ABSTRACT
Introduction: Anti-glomerular basement membrane (GBM) disease is a rare condition that often presents as severe glomerulonephritis and pulmonary hemorrhage. Heparin-induced thrombocytopenia (HIT) is a well-known but uncommon complication of heparin exposure that is characterized by autoantibodies against platelet factor 4 (PF4)/heparin complexes. Although these conditions are well described in the literature, the coexistence of HIT and anti-GBM glomerulonephritis is extremely rare.
Case Report: We present a case of a 59-year-old gentleman with newly diagnosed anti-GBM glomerulonephritis who was treated with plasmapheresis and subsequently developed HIT with a delayed manifestation.
Conclusion: This case demonstrates an interesting example of poly-autoimmunity and highlights the importance of platelet monitoring in patients with heparin exposure undergoing plasmapheresis.
Keywords: Glomerulonephritis, Heparin-induced thrombocytopenia
SUPPORTING INFORMATION
Author Contributions
Rebecca Xu - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Minh Huan Dang - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Rebecca Xu et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
