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Case Report
A case of thymic non-papillary adenocarcinoma
1 Department of Thoracic Surgery, National Defense Medical College, Saitama 359-8513, Japan
2 Department of Pathology and Laboratory Medicine, National Defense Medical College, Saitama, Japan
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Hiroshi Hashimoto
Department of Thoracic Surgery, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513,
Japan
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Article ID: 101039Z01HH2019
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Hashimoto H, Ozeki Y, Kameda K, Shimazaki H, Taguchi S. A case of thymic non-papillary adenocarcinoma. Int J Case Rep Images 2019;10:101039Z01HH2019.ABSTRACT
Introduction: Primary thymic adenocarcinoma is a notably rare neoplasm. Here, we described a case of non-papillary thymic adenocarcinoma that was comparable to adenocarcinoma not otherwise specified (NOS) according to the recent WHO classification.
Case Report: A 69-year-old woman presented to our hospital with an anterior mediastinal tumor. Thymothymectomy was performed. Histological examination revealed dense proliferation of irregular tubular and partially solid atypical cells with fibrous stroma. Based on pathological and immunohistochemical findings, and the absence of primary tumors in other sites, a diagnosis of primary thymic adenocarcinoma NOS was established. Recently, enteric-type adenocarcinoma was detected in a subset of adenocarcinoma NOS, but the current case was not of this type. The patient was alive without any sign of recurrence 30 months postoperatively.
Conclusion: Our case report suggests that some adenocarcinomas NOS are not enteric and that this finding should be further evaluated.
Keywords: Adenocarcinoma, Anterior mediastinal tumor, Thymic carcinoma
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Author Contributions
Hiroshi Hashimoto - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Yuichi Ozeki - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Koji Kameda - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Hideyuki Shimazaki - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Shinichi Taguchi - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2019 Hiroshi Hashimoto et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
