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Case Report
Alport syndrome with pelvic leiomyomatosis: The role of hormonal suppression
1 Women’s Clinic, Ghent University Hospital, 9000 Ghent, Belgium
2 Department of Urology, Ghent University Hospital, 9000 Ghent, Belgium
3 Department of Radiology and Nuclear Medicine, Ghent University Hospital, 9000 Ghent, Belgium
Address correspondence to:
Céline Verougstraete
Leemstraat 24–2800 Mechelen, Antwerp,
Belgium
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Article ID: 100125Z08CV2022
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Verougstraete C, Decaestecker K, De Visschere P, Hamerlynck T. Alport syndrome with pelvic leiomyomatosis: The role of hormonal suppression. J Case Rep Images Obstet Gynecol 2022;8(2):7–11.ABSTRACT
Introduction: Alport syndrome with diffuse pelvic leiomyomatosis is a complex combination for which the course of treatment is not well described. This case describes the outcomes of a trial with gonadotropin-releasing hormone analogues as an alternative to extensive surgery.
Case Report: A 47-year-old female patient, known with Alport syndrome associated with diffuse leiomyomatosis, was referred to our gynecological service because of a pelvic mass. The patient complained of obstipation and pain in the right hypochondrium. Magnetic resonance imaging showed a diffuse multi-lobulated leiomyomatosis from the vulvar to the perineal area. As the removal of the mass would imply very extensive surgery, conservative treatment options were searched for, in analogy with the medical treatment of uterine leiomyomas. A few trials used gonadotropin-releasing hormone analogues in the treatment of diffuse pelvic leiomyomatosis but follow-up data of these articles are lacking. For this patient, who was close to menopausal age, a trial therapy with gonadotropin-releasing hormone analogues was followed by an adnexectomy for total hormonal suppression. The patient’s follow-up showed stabilization of the mass and decrease of the pain complaints.
Conclusion: This case demonstrates that hormonal suppression can be a successful alternative to complex surgery in a case combining Alport syndrome and diffuse pelvic leiomyomatosis.
Keywords: Alport syndrome, Diffuse leiomyomatosis, GnRH analogues, Pelvic leiomyomatosis
SUPPORTING INFORMATION
Author Contributions
Céline Verougstraete - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Karel Decaestecker - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Pieter De Visschere - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Tjalina Hamerlynck - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 Céline Verougstraete et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
