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Case Report
Malignancy, a real risk in patients using anti-TNF drugs for Crohn’s disease?
1 Medical student, School of Medicine, Universidad Popular del Estado de Tlaxcala, Tlaxcala, Mexico
2 Medical Resident, Department of Anatomical Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
3 Medical student, Faculty of Medicine, Universidad Autónoma de Coahuila, Unidad Torreón, Mexico
4 Adjunct Professor of Pathology, Department of Anatomical Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Address correspondence to:
Braulio Martínez-Benitez
Department of Anatomical Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City,
Mexico
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Article ID: 100077Z11KD2024
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How to cite this article
Díaz KG, Rodriguez-Paredes GG, Lizardo-Thiebaud MJ, Prado-Aguirre A, Burbano-Rodriguez S, Martínez-Benitez B. Malignancy, a real risk in patients using anti-TNF drugs for Crohn’s disease? J Case Rep Images Pathol 2024;10(2):1–6.ABSTRACT
Introduction: Crohn’s disease (CD) is a subtype of inflammatory bowel disease. Mucosal healing has become the main target in therapy and the most consequential treatment has been biologic agents, such as anti-TNF agents. The benefits of anti-TNF agents are associated with an increase in the risk of opportunistic infections and the development of malignancies.
Case Report: A 58-year-old woman with the diagnosis of a stricturing, non-penetrating Crohn’s disease, underwent a surgical intervention for treatment of both Crohn’s disease and an ovarian tumor. The diagnosis was of two primary tumors, an ovarian and an endometrial carcinoma.
Conclusion: The association between the use anti-TNF agents and tumors has been narrowed to specific tumors. There is no association between the development of genitourinary tumors and treatment with anti-TNF agents. However, current data has demonstrated synchronicity between IBD and endometriosis. The pro-inflammatory profile seen in IBD might enhance the occurrence and transformation of endometriotic foci. Their link to ovarian tumors seen in IBD patients remains an open question.
Keywords: Anti-TNF, Crohn’s disease, Endometrial cancer, Ovarian cancer
SUPPORTING INFORMATION
Author Contributions
Karla Gabriela Díaz - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Final approval of the version to be published
Grecia Guadalupe Rodriguez-Paredes - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Final approval of the version to be published
María José Lizardo-Thiebaud - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Alessandra Prado-Aguirre - Acquisition of data, Analysis of data, Drafting the article, Final approval of the version to be published
Sara Burbano-Rodriguez - Acquisition of data, Analysis of data, Drafting the article, Final approval of the version to be published
Braulio Martínez-Benitez - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Karla Gabriela Díaz et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
