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Case Report
Intramucosal goblet cell adenocarcinoma: The evil got nipped in the bud
1 The Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA
2 MD, Attending General Surgeon, Department of Surgery, United Health Services, Binghamton, NY, USA
3 Medical Director and Chairman, Department of Pathology and Laboratory Medicine, United Health Services, Binghamton, NY, USA
Address correspondence to:
John Yablonski
MLitt, The Norton College of Medicine at SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210,
USA
Message to Corresponding Author
Article ID: 100071Z11JY2023
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Yablonski J, Tvetenstarnd CD, Sidhu J. Intramucosal goblet cell adenocarcinoma: The evil got nipped in the bud. J Case Rep Images Pathol 2023;9(1):22–28.ABSTRACT
Introduction: Appendiceal goblet cell adenocarcinoma is a rare cancer that usually has histological features of both well-differentiated carcinoid tumors and adenocarcinomas (neuroendocrine cells are not required for the diagnosis). Appendiceal goblet cell adenocarcinoma can present as acute appendicitis, abdominal pain, a mass, or be discovered incidentally following appendectomy.
Case Report: A 67-year-old female presented with signs of acute appendicitis and underwent laparoscopic appendectomy. Pathological evaluation showed evidence of both acute appendicitis/periappendicitis and an incidental appendiceal intramucosal well-differentiated adenocarcinoma in the lamina propria of a 12 mm long segment in the middle of the proximal half of the appendix.
Conclusion: Appendiceal goblet cell adenocarcinoma can sometimes be an incidental finding. It can be difficult to identify it, especially when it is in the form of only a few cells and clusters of cells limited to lamina propria. This case is the first reported incidence of an intramucosal goblet cell adenocarcinoma that was present in a 12 mm long segment in the middle of the proximal half of the appendix. The location of this tumor provides justification for making submission of an appendix in its entirety for histologic examination as a standard-of-care.
Keywords: Acute appendicitis, Adenocarcinoma, Appendiceal goblet cell adenocarcinoma, Carcinoid tumor
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Author Contributions
John Yablonski - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Christian D Tvetenstarnd - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Jagmohan Sidhu - Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2023 John Yablonski et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
