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Case Report
Primary pulmonary malignant melanoma versus metastatic melanoma with indeterminate primary site
1 Resident, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
2 Associate Professor, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
3 Associate Professor, Department of Surgery, Division of Thoracic Surgery, McMaster University, Hamilton, Ontario, Canada
4 Professor, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Address correspondence to:
Harpreet Rai
Department of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8,
Canada
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Article ID: 100062Z11HR2022
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How to cite this article
Rai H, Naqvi AH, Hanna WC, Alowami SO. Primary pulmonary malignant melanoma versus metastatic melanoma with indeterminate primary site. J Case Rep Images Pathol 2022;8:100062Z11HR2022.ABSTRACT
Introduction: Primary malignant melanoma of the lung is an extremely rare entity with a dismal prognosis.
Case Report: Herein, we present a case of primary malignant melanoma of the lung in a 67-year-old woman with a history of chest infection and a suspicious lesion on a chest X-ray. Computed tomography scan of the chest confirmed a nodule in the left lower lobe. Positron emission tomography showed a hypermetabolic tumor with no evidence of metastatic disease or mediastinal lymphadenopathy. The patient subsequently underwent surgery. Histopathological examination, supported by immunohistochemical analysis, was in accordance with malignant melanoma.
Conclusion: Since the published data focusing on cases of primary malignant melanoma of the lung are limited, the pathological features of these melanomas, their histogenesis, clinical behavior, and the possible therapeutic options are not well established.
Keywords: BRAF, Lung, Malignant melanoma
SUPPORTING INFORMATION
Author Contributions
Harpreet Rai - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Asghar H Naqvi - Analysis of data, Revising it critically for important intellectual content, Final approval of the version to be published
Waël C Hanna - Analysis of data, Drafting the article, Final approval of the version to be published
Salem O Alowami - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 Harpreet Rai et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
