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Chronic intestinal pseudo-obstruction due to eosinophilic myenteric ganglionitis: A report of two cases
1 Carle Illinois College of Medicine, 807 S. Wright Street, Champaign, IL 61820, USA
2 Department of Colorectal Surgery, Carle Foundation Hospital, 611 W. Park Street, Urbana, IL 61801, USA
3 Department of Pathology, Carle Foundation Hospital, 611 W. Park Street, Urbana, IL 61820, USA
Address correspondence to:
Ike Uzoaru
MD, Department of Pathology, Carle Foundation Hospital and Carle Illinois College of Medicine, 611 W. Park Street, Urbana, IL 61801,
USA
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Article ID: 100059Z11KC2022
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Cordner K, Tender P, Uzoaru I. Chronic intestinal pseudo-obstruction due to eosinophilic myenteric ganglionitis: A report of two cases. J Case Rep Images Pathol 2022;8:100059Z11KC2022.ABSTRACT
Eosinophilic myenteric ganglionitis (EMG) is a rare cause of chronic intestinal pseudo-obstruction (CIPO). While patients are typically in the first decade of life, and predominantly female, rare cases can be seen in adults. Patients present with constipation, abdominal distention, and tenderness with surgery as the mainstay of treatment. While outcomes are normally favorable after surgery, malnutrition, and surgical errors can lead to postoperative complications. A high index of suspicion for EMG, albeit rare, should be entertained in cases of CIPO since these patients usually have normal colonoscopy and/or biopsies due to the involvement of the myenteric plexus and sparing of the submucosal plexus. We report two cases of patients who underwent colon resection for CIPO complicated by sigmoid volvulus, and histologically characterized by colonic EMG and hypoganglionosis.
Keywords: Chronic intestinal pseudo-obstruction, Eosinophilic myenteric ganglionitis, Hypoganglionosis, Megacolon, Sigmoid volvulus
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Acknowledgments
The authors acknowledge here individuals who contributed to the work but do not qualify for authorship.
Author ContributionsKeith Cordner - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Paul Tender - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ike Uzoaru - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 Keith Cordner et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
