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Case Report
A case report of eccrine porocarcinoma with metastatic spread
1 Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, IL, USA
2 Department of Pathology, Carle Foundation Hospital, Urbana, IL, USA
3 Department of Radiology, Carle Foundation Hospital, Urbana, IL, USA
Address correspondence to:
Bradley Kaptur
MS, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign ???? 1406 W. Green St????, Urbana, IL 61801,
USA
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Article ID: 100057Z11BK2021
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How to cite this article
Kaptur B, Peterman N, Cordner K, Uzoaru I, Jimenez J. A case report of eccrine porocarcinoma with metastatic spread. J Case Rep Images Pathol 2021;7:100057Z11BK2021.ABSTRACT
Introduction: Eccrine porocarcinoma (EPC) is a rare malignant neoplasm arising from the eccrine sweat glands. Metastatic presentation of EPC is a rare complication of the disorder.
Case Report: A 62-year-old man presented with a longstanding skin lesion on his right forearm. A punch biopsy specimen demonstrated ulcerative, highly infiltrative carcinoma extending throughout the dermis into the cutis. The tumor cells were positive for cytokeratin 5, cytokeratin 7, p63, and p40. Additionally, immunostains showed positive epithelial membrane antigen (EMA), focal positive S100, negative carcinoembryonic antigen (CEA), and negative Melan A. They showed areas of ductular differentiation, and lymphovascular invasion was found to be present. Positron emission tomography (PET) and magnetic resonance imaging (MRI) demonstrated distant metastases, with a prominent large necrotic mass in the left leg.
Conclusion: Eccrine porocarcinoma is often misidentified initially, and there is no clear consensus on the best treatment approach.
Keywords: Eccrine porocarcinoma, Eccrine poroma, Metastatic skin malignancy, Skin lesion
SUPPORTING INFORMATION
Author Contributions
Bradley Kaptur - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Nicholas Peterman - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Keith Cordner - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ikechukwu Uzoaru - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Juan Jimenez - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Bradley Kaptur et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
