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Case Report
Mixed neuroendocrine and squamous rectal carcinoma: A poor prognosis
1 Surgical Intern, Department of Colorectal Surgery, Galway Clinic, Doughiska, Galway, Ireland
2 Consultant Pathologist, Department of Pathology, Galway Clinic, Doughiska, Galway, Ireland
3 Consultant Colorectal Surgeon, Department of Colorectal Surgery, Galway Clinic, Doughiska, Galway, Ireland
4 Royal College of Surgeons in Ireland, Ireland
Address correspondence to:
Radha Senaratne
Suite 4, Galway Clinic, Doughiska, Galway,
Ireland
Message to Corresponding Author
Article ID: 100050Z11RS2021
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How to cite this article
Senaratne R, Curran S, Joyce W. Mixed neuroendocrine and squamous rectal carcinoma: A poor prognosis. J Case Rep Images Pathol 2021;7:100050Z11RS2021.ABSTRACT
Introduction: Colorectal cancer is one of the most common cancers diagnosed globally with the majority being adenocarcinomas. Mixed tumors can occur, however, it is very rare for no adenocarcinoma component to be present.
Case Report: We describe a patient who presented with a recto-sigmoid tumor and subsequently underwent a low anterior resection. She unfortunately developed metastatic disease and died three months after surgery. Histological analysis of the resected specimen showed a mixed neuroendocrine and squamous carcinoma with no features of adenocarcinoma.
Conclusion: Mixed neuroendocrine carcinoma with a squamous component is a very unusual histopathological subtype of colorectal cancer. It can metastasize rapidly and carries a poor prognosis.
Keywords: Carcinoma, Neuroendocrine, Rectal cancer, Squamous
SUPPORTING INFORMATION
Author Contributions
Radha Senaratne - Acquisition of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Stephanie Curran - Substantial contributions to conception and design, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
William Joyce - Substantial contributions to conception and design, Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient’s next-of-kin for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Radha Senaratne et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
