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Case Report
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| Autoimmune thyroiditis and thyroid cancer in a child with lymphocytic infundibuloneurohypophysitis | ||||||
| Mirjana Kocova1, Daniela Pop Gjorcheva2, Elena Kochova3 | ||||||
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1MD, PhD, Department of Endocrinology, University Pediatric Clinic, Skopje, Macedonia.
2MD, PhD, Institute of Pathophysiology and Nuclear Medicine "Isak S. Tadzer", Skopje, Macedonia. 3MD, Medical Neuroscience Program, Charité Universitätsmedizin, Berlin, Germany. | ||||||
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| How to cite this article |
| Kocova M, Gjorcheva DP, Kochova E. Autoimmune thyroiditis and thyroid cancer in a child with lymphocytic infundibuloneurohypophysitis. Int J Case Rep Images 2016;7(12):853–857. |
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Abstract
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Introduction:
Lymphocytic infundibuloneuro-hypophysitis (LINH) is a chronic autoimmune inflammation of the posterior pituitary and pituitary stalk which is found only exceptionally in children. Its long-term evolution and the association with other autoimmune diseases are largely unexplored.
Case Report: ith diabetes insipidus was diagnosed with LINH based on the MRI findings. She was treated with desmopressin acetate spray. One year later autoimmune thyroiditis developed with increased thyroid peroxidase antibodies and typical ultrasonographic finding. Due to normal thyroid hormone levels, the girl was not treated with levothyroxine. A large thyroid nodule developed within two years. The standard diagnostic and therapeutic procedures and follow-up for both diseases were undertaken. The LINH had a favorable evolution with regression of the pituitary swelling on MRI, but with permanent diabetes insipidus, whereas the thyroid nodule progressed towards thyroid papillary/follicular carcinoma and was treated surgically with subsequent L-thyroxin substitution. Conclusion: This thus-far unreported combination of a rare and a common autoimmune disease in a pediatric patient demonstrates the possible simultaneity and independent evolution of autoimmune thyroiditis and lymphocytic infundibuloneurohypophysitis. | |
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Keywords:
Association, Autoimmune thyroiditis, Child, Disease progression, Lymphocytic infundibuloneurohypophysitis
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Author Contributions
Mirjana Kocova – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Daniela Pop Gjorcheva – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Elena Kochova – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2016 Mirjana Kocova et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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