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Case Report
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| Recurrent posterior reversible encephalopathy syndrome in a patient with focal segmental glomerulosclerosis: A case report | ||||||
| Nathasha Vihangi Luke1, Sumudu Sajeewa Wickramasinghe2, Udaya K. Ranawaka3 | ||||||
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1MBBS, Registrar in clinical medicine, Professorial Medical Unit, North Colombo Teaching Hospital and Lecturer, Department of Clinical Pharmacology, Faculty of Medicine, University of Kelaniya, Sri Lanka.
2MBBS, Registrar in clinical medicine, Professorial Medical Unit, North Colombo Teaching Hospital, Sri Lanka. 3MBBS, MD, MRCP, FRCP, Consultant Neurologist, Professorial Medical Unit, North Colombo Teaching Hospital and Senior Lecturer, Department of Medicine, University of Kelaniya, Sri Lanka. | ||||||
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| How to cite this article |
| Luke NV, Wickramasinghe SS, Ranawaka UK. Recurrent posterior reversible encephalopathy syndrome in a patient with focal segmental glomerulosclerosis: A case report. Int J Case Rep Images 2016;7(11):706–709. |
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Abstract
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Introduction:
Posterior reversible encephalopathy syndrome (PRES) is a rare clinical syndrome of which the aetiology and pathogenesis still remain unknown. We present a rare case of recurrent PRES in a patient with adult onset nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS).
Case Report: A 30-year-old Asian female with FSGS on renal biopsy developed two episodes of PRES with residual neurological deficits without significant hypertension. Both these episodes were preceded by initiation of treatment with calcineurin inhibitors for persistent proteinuria. She was subsequently started on mycophenolate mofetil without further recurrences of PRES. Conclusion: Although PRES is well recognized, this case has a combination of several unusual features that merit special attention. Recurrent PRES, and its association with focal segmental glomerulosclerosis, are extremely rare. Furthermore, development of PRES without significant hypertension and persistent neurological sequelae are rare findings. The association between FSGS and PRES has been previously noted but to our knowledge this is the first case of recurrent PRES in a patient with FSGS. | |
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Keywords:
Focal segmental glomerulosclerosis, Nephrotic syndrome, Posterior reversible encephalopathy syndrome, Recurrences
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Author Contributions
Nathasha Vihangi Luke – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Sumudu Sajeewa Wickramasinghe – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Udaya K. Ranawaka – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2016 Nathasha Vihangi Luke et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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