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Case Report
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| Monotherapy with erythromycin results in severe rhabdomyolysis | ||||||
| Lukas Birkner1, Dimitri Zolotov1,2, Mario Iasevoli1 | ||||||
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1MD, Department of Internal Medicine, Ev, Krankenhaus Witten gGmbH, University of Witten/Herdecke, Pferdebachstr, 27, 58455 Witten, Germany.
2MD, Dialysis Practice of Internal and nephrology Medicine, Pferdebachstr. 11, 58455 Witten, Germany. | ||||||
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| How to cite this article |
| Birkner L, Zolotov D, Iasevoli M. Monotherapy with erythromycin results in severe rhabdomyolysis. Int J Case Rep Images 2016;7(8):551–553. |
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Abstract
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Introduction:
Rhabdomyolysis is a potentially life-threatening condition caused by muscle necrosis and extravasation of intracellular muscle contents into the blood circulation. An elevation in serum creatine kinease is most confirmatory laboratory test. Erythromycin is an inhibitor of the CYP3A4 enzyme system which is responsible for the metabolism of several drugs, particularly some statins. Although rhabdomyolysis asssociated with macrolid-statin interaction has been previously described, we report the first case of erythromycin-induced rhabdomyolysis.
Case Report: In our case, a 38-year-old male admitted with pneumonia developed rhabdomyolysis associated with erythromycin administration. Conclusion: Clinicians need to be aware of the risks this potential adverse drug reaction poses. | |
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Keywords:
Erythromycin, Penicillin intolerance, Pneumonia, Rhabdomyolysis
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Author Contributions
Lukas Birkner – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Dimitri Zolotov – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Mario Iasevoli – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2016 Lukas Birkner et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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