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Case Report
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| A case of ganglioneuroma of the colon during routine colonoscopy | ||||||
| Michael Herman1, Jean Abed1, Wenjing Shi2, Arzu Buyuk2, Pavan Kumar Mankal3, Donald Kotler3, Gabriel Ionescu1,3 | ||||||
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1Department of Medicine, Mount Sinai St. Luke's and Mount Sinai Roosevelt Hospitals, Icahn School of Medicine, New York, NY.
2Department of Pathology, Mount Sinai St. Luke's and Mount Sinai Roosevelt Hospitals, Icahn School of Medicine, New York, NY. 3Division of Gastroenterology, Mount Sinai St. Luke's and Mount Sinai Roosevelt Hospitals, Icahn School of Medicine, New York, NY. | ||||||
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| How to cite this article |
| Herman M, Abed J, Shi W, Buyuk A, Mankal PK, Kotler D, Ionescu G. A case of ganglioneuroma of the colon during routine colonoscopy. Int J Case Rep Images 2015;6(9):560–563. |
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Abstract
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Introduction:
Colonic ganglioneuromas are classified as hamartomatous polyps that are composed of ganglion cells, nerve fibers, and enteric nervous system cells. The GNs of the gastrointestinal tract can be classified into three groups based on the size and the number of polyps: polypoid GN, ganglioneuromatous polyposis, and diffuse ganglioneuromatosis. Polypoid GNs, seen in patients with Cowden's syndrome, are small, sessile or pedunculated polyps that have a similar appearance to hyperplastic and adenomatous polyps. Ganglioneuromatous polyposis, seen most commonly in patients with MEN IIB, NF1, Cowden's syndrome, usually manifests as more than 20 sessile or pedunculated polyps. Lastly, diffuse ganglioneuromatosis, seen in MEN IIB7 and NF1, involves proliferation of neuronal cells in the entire colon, but does not extend into the ileum.
Case Report: A 57-year-old African-American male with a history of untreated chronic hepatitis C cirrhosis with viral load of over 4 million copies, seizure disorder, mild mental retardation, hypothyroidism, hypertension, diabetes mellitus type 2, presented to the gastroenterology clinic for scheduling of a screening colonoscopy. At that time, he was completely asymptomatic. On colonoscopy, one 4 mm sessile polyp was resected in the sigmoid colon and was histologically diagnosed as a ganglioneuroma (GN). Conclusion: The finding of an asymptomatic, solitary GN in our patient does not warrant more frequent colon cancer screening given its benign nature. | |
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Keywords:
Cancer, Colonoscopy, Cowden's syndrome, Ganglioneuroma, Neurocutaneous syndromes
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Author Contributions
Michael Herman – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Jean Abed – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Wenjing Shi – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Pavan Kumar Mankal – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Donald Kotler – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Gabriel Ionescu – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2015 Michael Herman et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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