  |
|
 |
|
Case Report
| ||||||
| Generalized chloromas with multiple cranial nerves palsies in a patient with chronic myeloid leukemia in a tertiary institution in South-south Nigeria: A case report | ||||||
| Mabel Ino-Ekanem1, Timothy Amos Ekwere1 | ||||||
|
1MB,BCh, FMCPath, Lecturer 1& Consultant Hematologist, Department of Hematology, University of Uyo/ University of Uyo Teaching Hospital, Uyo, AkwaIbom State, Nigeria.
| ||||||
| ||||||
|
[HTML Full Text]
[PDF Full Text]
[Print This Article]
[Similar article in Pumed] [Similar article in Google Scholar] 
|
| How to cite this article |
| Ino-Ekanem, M, Ekwere TA. Generalized chloromas with multiple cranial nerves palsies in a patient with chronic myeloid leukemia in a tertiary institution in South-south Nigeria: A case report. Int J Case Rep Images 2014;5(12):822–825. |
|
Abstract
|
|
Introduction:
Chloromas or granulocytic sarcomas are extramedullary granulocytic tumors which occur in acute myeloid leukemia (AML), myeloproliferative disorders and myelodysplastic syndromes. They are composed of myeloid blast and herald the onset of systemic relapse.
Case Report: We report a rare case of 49-year-old male with generalized chloromas in chronic myeloid leukemia (CML) associated with multiple cranial nerves deficit suggesting an intracranial involvement. The central nervous system (CNS) is considered to be an uncommon site for chloromas. Treatment with hydroxyurea was unremarkable as the chloroma became more widespread and neurological deficit worsen. This study brings to fore this rare presentation and the apparent limitation of hydroxyurea (cytoreductive therapy) in patient management. Conclusion: Widespread florid chloromas presenting in chronic phase of CML with associated CNS manifestation is rare. The response to Initial therapy with hydroxyurea was unremarkable. The patient was discharged against medical advice and thus lost to follow-up. | |
|
Keywords:
Chloromas (myeloid sarcoma), Chronic myeloid leukemia, Hydroxyurea, Granulocytic sarcoma
| |
|
[HTML Full Text]
[PDF Full Text]
|
|
Author Contributions
Mabel Ino-Ekanem – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Timothy Amos Ekwere – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
|
Guarantor of submission
The corresponding author is the guarantor of submission. |
|
Source of support
None |
|
Conflict of interest
Authors declare no conflict of interest. |
|
Copyright
© 2014 Mabel Ino-Ekanem et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
|
|