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Case Report
 
Malignant mucosal melanoma of the nasal cavity: A case report
Devika Gupta1, Niti Goyal2, Vandana Rana3, Rajat Jagani4, Davendra Swarup5
1MD, DNB Pathology, Assistant Professor, Armed Forces Medical College, Department of Pathology and Laboratory Science, Command Hospital, Pune, India.
2Resident, MD, Pathology, Armed Forces Medical College, Department of Pathology and Laboratory Science, Command Hospital, Pune, India.
3MD, Pathology, Assistant Professor, Armed Forces Medical College, Department of Pathology and Laboratory Science, Command Hospital, Pune, India.
4MD, Pathology, Associate Professor, Armed Forces Medical College, Department of Pathology and Laboratory Science, Command Hospital, Pune, India.
5Professor, Armed Forces Medical College, Department of Pathology and Laboratory Science, Command Hospital, Pune, India.

doi:10.5348/ijcri-2014111-CR-10422

Address correspondence to:
Devika Gupta
MD, DNB, Pathology, Assistant Professor
Armed Forces Medical College, Department of Pathology and Laboratory Science Command Hospital
Pune - 411040
India
Phone: 9158984335
Email: devikalives5h@gmail.com

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How to cite this article
Gupta D, Goyal N, Rana V, Jagani R, Swarup D. Malignant mucosal melanoma of the nasal cavity: A case report. Int J Case Rep Images 2014;5(9):629–633.


Abstract
Introduction: Mucosal melanoma of the nasal cavity is a rare tumor. It is seen more commonly in the elderly and is known to have a male preponderance. Patients often present with non-specific symptoms of nasal obstruction or epistaxis. These tumors carry a poor prognosis because of higher rates of locoregional recurrence and distant metastasis.
Case Report: We report a 54-year-old male who presented with submandibular swelling and history of episodes of occasional epistaxis. Microscopic examination of the excision biopsy of the submandibular lymph node supported with immunohistochemistry (IHC) was suggestive of metastatic deposit of malignant melanoma. Clinical examination and radiological imaging for the primary tumor lead to detection of a mass in the right nasal cavity. Histopathology of wide local excision of nasal mass confirmed the diagnosis.
Conclusion: Malignant melanomas can mimic a large number of malignant diseases and early diagnosis by astute pathologist can help achieve attain long time remission.

Keywords: Malignant diseases, Melanoma, Nasal cavity, Nasal mass, Sinonasal tract, HMG-45


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Author Contributions
Devika Gupta – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Niti Goyal – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Vandana Rana – Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Rajat Jagani – Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Davendra Swarup – Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2014 Devika Gupta et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



About The Authors

Devika Gupta is Assistant Professor in Department of Pathology, Armed Forces Medical College, Pune, India. She has earned the undergraduate degree MBBS from Armed Forces Medical College (Pune University), India and postgraduate degree of MD Pathology and DNB Pathology from Delhi University, India. Her research interests include hematolymphoid malignancies and blood coagulation disorders. She intends to pursue fellowship in transplant immunology in future.



Niti Goyal is final year Resident Pathology in the Department of Pathology at Armed Forces Medical College, Pune, India. She earned the undergraduate degree (MBBS) from, India. She has keen interest in oncopathology and wants to pursue her fellowship in same.



Vandana Rana is Associate Professor in Department of Pathology, Command Hospital, Pune, India. She has earned her MBBS and MD (Pathology) from PGIMS Rohtak, Haryana, India. She has been working in the field of oncopathology for last seven years. Her research interests include breast and lymphoid malignancies. She has active interest in teaching and intends to keep on upgrading and expanding her horizons.



Rajat Jagani is Associate Professor in Department of Pathology, Command Hospital, Pune, India. He earned the undergraduate degree MBBS from University of Pune, Pune Maharashtra, India and postgraduate degree form University of Pune, Pune Maharashtra, India. (Long-term Training in oncopathology at Post-graduate Institute of Medical Education and Research, Chandigarh India). He has published seven research papers in national and international academic journals. His research interests include prostate pathology, breast pathology and effusion cytology. He intends to pursue PhD in oncopathology in future.



Davendra Swarup is HOD Pathology in Department of Pathology, Command Hospital, Pune, India. He passed his MBBS and MD (Pathology) from Agra University, India. He has teaching experience of 14 years for both undergraduate and postgraduate students. His research interests include histopathology and transfusion medicine.