  |
|
 |
|
Case Report
| ||||||
| A young female with catastrophic antiphospholipid syndrome | ||||||
| Vivekanandan Senthamil Pari1, Lakshmi M2, Sampath Kumar3, Sathyamurthy P4, Sudhakar MK5, Sandhya Sundaram6 | ||||||
|
1Post Graduate Student, Department of Medicine, Sri Ramachandra Medical College & Research Institute, Porur, Chennai, Tamil Nadu, India.
2DNB in Internal Medicine, Senior Resident, Department of Medicine, Sri Ramachandra Medical College & Research Institute, Chennai, Tamil Nadu, India. 3MD in Internal Medicine, Assistant professor, Department of Medicine, Sri Ramachandra Medical College & Research Institute, Porur, Chennai, Tamil Nadu, India. 4MD in Internal Medicine, Associate Professor, Department of Medicine, Sri Ramachandra Medical College & Research Institute, Chennai, Tamil Nadu, India. 5MD in Internal Medicine, Professor & Head of Department, Department of Medicine, Sri Ramachandra Medical College & Research Institute, Chennai, Tamil Nadu, India. 6MD in Pathology, Professor & Senior Consultant, Department of Pathology, Sri Ramachandra Medical College & Research Institute, Chennai, Tamil Nadu, India. | ||||||
| ||||||
|
[HTML Full Text]
[PDF Full Text]
[Print This Article]
[Similar article in Pumed] [Similar article in Google Scholar] 
|
| How to cite this article |
| Pari VS, Lakshmi M, Kumar S, Sathyamurthy P, Sudhakar MK, Sundaram S. A young female with catastrophic antiphospholipid syndrome. Int J Case Rep Images 2014;5(7):513–518. |
|
Abstract
|
|
Introduction:
Antiphospholipid syndrome is characterized by recurrent thrombosis and/or pregnancy loss with the presence of circulating antiphospholipid antibodies. Its clinical manifestations range from asymptomatic to catastrophic antiphospholipid syndrome. This condition is a rare presentation of antiphospholipid syndrome and has a very high mortality rate.
Case Report: Herein, we present a 20-year-old female patient are presented with peripheral cyanosis, computed tomography angiogram of abdomen and lower limb vessels showed arterial occlusion, and renal infarcts. She also developed seizures during hospital stay. With suspicion of vasculitis she was started on methyl prednisolone with other appropriate medications after sending blood for relevant investigations. She responded to medications, meanwhile her antiphospholipid antibody was positive with skin biopsy taken from affected limb showing microthrombi in dermal capillaries with inflammatory exudates. These features are in favor of a diagnosis of a catastrophic antiphospholipid syndrome, which will be discussed in this case report. Conclusion: Catastrophic antiphospholipid syndrome is a rare entity occurring in 0.8–1% of patients with antiphospholipid antibody syndrome and it has a very poor prognosis. But early, aggressive treatment improves the recovery rate and requires a high degree of suspicion. | |
|
Keywords:
Recurrent thrombosis, Catastrophic antiphospholipid syndrome, Antiphospholipid antibodies
| |
|
[HTML Full Text]
[PDF Full Text]
|
|
Author Contributions
Vivekanandan Senthamil Pari – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Sampath Kumar – Acquisition of data, Drafting the article, Final approval of the version to be published Sathyamurthy P – Acquisition of data, Drafting the article, Final approval of the version to be published Sudhakar MK – Acquisition of data, Drafting the article, Final approval of the version to be published Sandhya Sundaram – Acquisition of data, Drafting the article, Final approval of the version to be published |
|
Guarantor of submission
The corresponding author is the guarantor of submission. |
|
Source of support
None |
|
Conflict of interest
Authors declare no conflict of interest. |
|
Copyright
© 2014 Vivekanandan Senthamil Pari et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
|
|
|
About The Authors
| |||
| |||
| |||
| |||
| |||
| |||
| |||
