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Case Report
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| Undifferentiated connective tissue disease presenting with vascular pattern of renal amyloidosis with carpel tunnel syndrome: A case report | ||||||
| Sham Sunder1, Satyanand Sathi2, Himanshu Mahapatra3, Rajesh J2, Anurag Gupta2, Prabhu K2 | ||||||
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1Professor, Department of Nephrology, PGIMER & Dr. Ram Manohar Lohia Hospital New Delhi, India.
2DM Student, Department of Nephrology, PGIMER & Dr. Ram Manohar Lohia Hospital New Delhi, India. 3Associate Professor, Department of Nephrology, PGIMER & Dr. Ram Manohar Lohia Hospital New Delhi, India. | ||||||
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| How to cite this article |
| Sunder S, Sathi S, Mahapatra H, Rajesh J, Gupta A, Prabhu K. Undifferentiated connective tissue disease presenting with vascular pattern of renal amyloidosis with carpel tunnel syndrome: A case report. Int J Case Rep Images 2014;5(6):417–422. |
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Abstract
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Introduction:
The undifferentiated connective tissue disease (UCTD) is the clinical entity where the patients share the clinical symptoms of different connective tissue diseases but do not satisfy the classification criteria of the American College of Rheumatology for a particular connective tissue disease.
Case Report: A 62-year-old female was presented with multiple joint pain, Raynaud's phenomenon, alopecia, swelling of legs, hardening of skin of the fingers of hands, and carpel tunnel syndrome. Antinuclear antibody test was moderately positive. Antibodies to double-stranded DNA and for antiphospholipid (lupus anticoagulant and anticardiolipin), anticentromere, anti-Scl-70, Anti-Jo1, U1-RNP Anti-Ro/SSA, Anti-La/SSB, were negative. RA factor was also negative. Twenty-four hour urine showed nephrotic range proteinuria and renal biopsy showed vascular pattern of renal amyloidosis with changes of interstitial fibrosis. The patient was diagnosed as having UCTD with vascular pattern of renal amyloidosis with carpel tunnel syndrome with nephrotic syndrome (NSAIDS induced minimal change nephropathy) with chronic kidney disease stage 3. Conclusion: Undifferentiated connective tissue disease may lead to renal involvement in the form of vascular pattern of renal amyloidosis. Raynaud's phenomenon and carpel tunnel syndrome both can, coexist and may herald inflammatory arthritis or an UCTD. | |
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Keywords:
Undifferentiated connective tissue disease, Vascular pattern of renal amyloidosis, Carpel tunnel syndrome
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Author Contributions
Sham Sunder – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Satyanand Sathi – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published Himanshu Mahapatra – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published Rajesh J – Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published Anurag Gupta – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published Prabhu K – Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2014 Sham Sunder et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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