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Review Article
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| Photodynamic therapy: A new modality treatment in pre-cancer and cancer patients | ||||||
| Nagalaxmi Velpula1, Kotya Naik Maloth2, Srikanth Kodangal3, Vani Chappidi4, Stuti Goyal3, Swapna Lingam3 | ||||||
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1MDS, Professor and Head, Sri Sai College of Dental Surgery, Vikarabad, Andhra Pradesh, India.
2MDS, Senior lecturer, Mamata Dental College, Khammam, Andhra Pradesh, India. 3MDS, Senior Lecturer, Sri Sai College of Dental Surgery, Vikarabad, Andhra Pradesh, India. 4MDS, Reader, Sri Sai College of Dental Surgery, Vikarabad, Andhra Pradesh, India. | ||||||
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| How to cite this article |
| Velpula N, Maloth KN, Kodangal S, Chappidi V, Goyal S, Lingam S. Photodynamic therapy: A new modality treatment in pre-cancer and cancer patients. International Journal of Case Reports and Images 2014;5(4):250–257. |
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Abstract
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Introduction:
Photodynamic therapy (PDT) is a new modality of therapy being used for the diagnosis and treatment in pre-cancer and cancer patients and various skin diseases. Photodynamic therapy is a powerful light-initiated photochemical reaction, involving the use of a photoactive dye (photosensitizer) activated by light of a specific wavelength in the presence of oxygen. This leads to the formation of oxygen free radicals which are toxic, which can damage proteins, lipids, nucleic acids and other components. Application of photodynamic therapy in dentistry is growing rapidly for the use of oral pre-cancers and cancer lesions, bacterial and fungal infections. Photodynamic antimicrobial chemotherapy (PACT) has been efficacious in the management of periodontal infections, peri-implantitis, endodontic infections and oral bio-films formation. The absence of genotoxic and mutagenic effects and no risk of developing resistance to its antimicrobial action made its use important. Photodynamic therapy is limited to superficial lesions at present. However, in future a deeper effect can be achieved by the developments in this technique. This review gives a general summary of the mechanism and clinical applications of photodynamic therapy.
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Keywords:
Photodynamic therapy (PDT), Photosensitizers, Photodynamic Antimicrobial chemotherapy (PACT)
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Author Contributions
Nagalaxmi Velpula – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Kotya Naik Maloth – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Srikanth Kodangal – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Vani Chappidi – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Stuti Goyal – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Swapna Lingam – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© Nagalaxmi Velpula et al. 2014; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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About The Authors
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