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Case Report
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| DRESS syndrome associated with allopurinol | ||||||
| Chidozie Charles Agu1, Hiba Basheer1 | ||||||
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1MD, Resident (Internal Medicine), Department of Internal Medicine. Interfaith Medical Center, 1545 Atlantic Avenue, Brooklyn, New York.
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| How to cite this article |
| Agu CC, Basheer H. DRESS syndrome associated with allopurinol. International Journal of Case Reports and Images 2014;5(2):145–149. |
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Abstract
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Introduction:
DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a severe drug reaction with an estimated mortality of up to 10% largely due to multi-organ dysfunction. Diagnosis is challenging because the extent of skin involvement does not always correlate with the extent of internal organ involvement and therefore early recognition of symptoms is vital to minimize morbidity and mortality. Management involves prompt cessation of the culprit drug, administration of corticosteroids and supportive treatment.
Case Report: We report a case of an 87-year-old female with medical history significant for stage five chronic kidney disease, recently started on allopurinol for gout presented with dizziness, skin rash and eosinophilia which rapidly progressed to shock state followed by altered mentation, worsening renal failure, severe metabolic acidosis, deranged liver enzymes and gastrointestinal bleed requiring blood transfusion. Conclusion: Allopurinol is commonly used in clinical practice for the treatment of symptomatic hyperuricemia and gout. It has been associated with DRESS syndrome especially when used indiscriminately. | |
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Keywords:
DRESS syndrome, Allopurinol, Multi-organ failure
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Author Contributions
Chidozie Charles Agu – Substantial contributions to conception and design, Acquisition of data, analysis and interpretation of data, drafting the article, Revising it critically for important intellectual content and final approval of the version to be published Hiba Basheer – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content and final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© Chidozie Charles Agu et al. 2014; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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