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Case Report
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| Primary systemic amyloidosis presenting at an early age: A case report | ||||||
| Arghya Chattopadhyay1, Shatarupa Dutta2, Amitava Majumder3, Jayanta Das4 | ||||||
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1unior Resident, Department of Medicine, Vivekananda Institute of Medical Sciences, 99, Sarat Bose Road, Kolkata -700026. West Bengal, India.
2Junior Resident, Department of Radiotherapy, Institute of Post graduate Medical Education and Research, Kolkata-700020, West Bengal, India. 3Assistant Professor, Department of Medicine, Vivekananda Institute of Medical Sciences, 99, Sarat Bose Road, Kolkata -700026. West Bengal India. 4Assistant Professor, Department of Dermatology, Vivekananda Institute of Medical Sciences,99,Sarat Bose Road, Kolkata -700026. West Bengal, India. | ||||||
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| How to cite this article: |
| Chattopadhyay A, Dutta S, Majumder A, Das J. Primary systemic amyloidosis presenting at an early age: A case report. International Journal of Case Reports and Images 2014;5(2):99–103. |
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Abstract
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Introduction:
Primary systemic amyloidosis arises from clonal B cell disorder and may be associated with myeloma or lymphoma. Amyloid deposition can occur in any organ in the body as well as skin lesions. Both sexes are affected by this disease, with onset most commonly in the sixth decade or after.
Case Report: A 26-year-old female was presented with gradually changing quality of voice, diffuse pigmentation all over body and lymphadenopathy in upper cervical group. Biopsy of a lymph node showed follicular hyperplasia with a few discrete large cells. Over a period of time, she developed purpuric rash over extremities and periorbital area, respiratory distress and heart failure. Echocardiography revealed cardiac amyloidosis and rectal biopsy with Congo red staining was positive for amyloidosis. Skin biopsy from hyperpigmented lesion of right forearm was also suggestive of amyloidosis and bone marrow examination showed plasma cell dyscrasia with a small M-band in serum protein electrophoresis. Finally, it was diagnosed a case of primary systemic amyloidosis. Conclusion: We report a primary systemic amyloidosis with an early age presentation. | |
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Keywords:
Primary systemic amyloidosis, Heart failure, Skin rash, Plasma cell disorder
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Author Contributions
Arghya Chattopadhyay – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content , Final approval of the version to be published Shatarupa Dutta – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published Amitava Majumdar – Substantial contributions to conception and design, Drafting the article, revising it critically for important intellectual content , Final approval of the version to be published Jayanta Das – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© Arghya Chattopadhyay et al. 2014; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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