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Case Report
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| Primary cerebellar B cell lymphoma: A case report | ||||||
| Anupam Datta1, Arunima Gupta1, Krishnangshu Bhanja Choudhury2, Aruj Dhyani2, Anup Majumdar3 | ||||||
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1Post Graduate trainee, Radiotherapy, Junior Resident, Department of Radiotherapy, Institute of Post graduate Medical Education and Research, Kolkata-700020, West Bengal, India.
2MD, Radiotherapy. RMO-cum-Clinical tutor, Department of Radiotherapy, R.G.Kar Medical College and Hospital, Kolkata -700004, West Bengal, India. 3MD, Radiotherapy, Professor and Head, Department of Radiotherapy, Institute of Post graduate Medical Education and Research, Kolkata-700020, West Bengal, India. | ||||||
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| How to cite this article: |
| Datta A, Gupta A, Choudhury KB, Dhyani A, Majumdar A. Primary cerebellar B cell lymphoma: A case report. International Journal of Case Reports and Images 2013;4(9):498–501. |
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Abstract
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Introduction:
Primary central nervous system lymphoma (PCNSL) is usually a diffuse large B cell non-Hodgkin lymphoma that originates in the brain, spinal cord, leptomeninges or eyes. Primary central nervous system lymphoma is a rare malignant tumor comprising less than 3% of all primary brain tumors. The PCNSL in immunocompetent patients is most commonly supratentorial, found adjacent to the ventricular surfaces and in deep white matter and subcortical structures, such as the basal ganglia, thalamus and corpus callosum. The lesion is single in 60–70% of patients. Lesions are located in the hemispheres (38%), thalamus/basal ganglia (16%), corpus callosum (14%), periventricular region (12%) and cerebellum (9%). Herein, we report an extremely rare case of a primary CNS B cell lymphoma involving cerebellum.
Case Report: A 55-year-old female was presented with vomiting, ataxia and disorientation. T2-weighted axial, T1-weighted and gadolinium-enhanced T1-weighted axial magnetic resonance imaging scans show a contrast enhancing mass with peritumoral edema in the right cerebellar hemisphere. Excision biopsy was suggestive of non-Hodgkin lymphoma. Diagnosis was confirmed with immunohistochemistry favoring non-Hodgkin lymphoma of diffuse large B cell type. This patient received cytotoxic therapy with carmustine 200 mg IV 6 weekly 3 cycles followed by external beam radiation therapy 30 Gy. No recurrence was noticed in one year follow-up. Conclusion: Primary B cell lymphoma limited to the CNS is exceedingly rare in the middle aged immunocompetent individual. Little is known regarding etiologic factors, optimal management and prognosis. | |
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Keywords:
Non-Hodgkin lymphoma, Carmustine, B-cell lymphoma, Cerebellum
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Author Contributions
Anupam Datta – Conception and design, Drafting the article, Critical revision of the article, Final approval of the version to be published Arunima Gupta – Conception and design, Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published Krishnangshu Bhanja Choudhury – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Aruj Dhyani – Conception and design, Drafting the article, Critical revision of the article, Final approval of the version to be published Anup Majumdar – Conception and design, Drafting the article, Critical revision of the article, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© Anupam Datta et al. 2013; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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