 |
|
 |
|
Case Report
| ||||||
| A case of massive aortic thrombosis with catastrophic cerebrovascular embolization and infarction | ||||||
| Aleksandra Mamorska-Dyga1, Doru Paul1, Ch. Khalil1, Ghulam Sajjad Khan1 | ||||||
|
1Lincoln Medical and Mental Health center, Department of Hematology Oncology.
| ||||||
| ||||||
|
[HTML Full Text]
[PDF Full Text]
[Print This Article]
[Similar article in Pumed] [Similar article in Google Scholar] 
|
| How to cite this article: |
| Mamorska-Dyga A, Paul D, Khalil C, Khan GS. A case of massive aortic thrombosis with catastrophic cerebrovascular embolization and infarction. International Journal of Case Reports and Images 2013;4(6):294–298. |
|
Abstract
|
|
Introduction:
Antiphospholipid syndrome (APS) is the most common type of acquired thrombophilia. Lupus anticoagulant (LA) is more commonly associated with venous than with arterial thrombosis and accounts for 6–8% of thrombotic events.
Case Report: A 50-year-old African-American male presented to the emergency department with right sided hemiparesis, facial droop and impaired speech. First symptoms were noted about 10–12 hours before presentation to the emergency department. During two weeks preceding admission, patient experienced several transient episodes of similar neurological deficits. Computed tomography (CT) scan of brain done on admission showed ischemic stroke involving the area of distribution of the left middle cerebral artery. The CT angiography of brain revealed a large thrombus in the aortic arch, left common carotid and internal carotid artery. Laboratory studies were positive for lupus anticoagulant. Serial brain CT scan demonstrated increasing brain edema and midline shift eventually leading to transtentorial herniation. Several days after admission, neurological examination revealed loss of brain stem reflexes. Conclusion: Antiphosphotipid syndrome (APS) is the most common type of acquired thrombophilia. Lupus anticoagulant is mainly associated with venous thrombosis and accounts for 6–8% of thrombotic events in otherwise healthy patients. Prompt diagnosis and treatment, with long-term anticoagulation for survivors is crucial. The most common site of arterial thrombosis in APS is central nervous system, presenting with stroke and transient ischemic attacks in 50% of the cases. Patients with diagnosed APS and prior thrombosis have high risk for recurrent events. Due to this fact some authors postulate lifelong anticoagulation therapy. | |
|
Keywords:
Antiphospholipid thrombosis syndrome, Acquired thrombophilia, Aortic thrombosis, Systemic embolization, Cerebrovascular embolization
| |
|
[HTML Full Text]
[PDF Full Text]
|
|
Author Contributions
Aleksandra Mamorska-Dyga – Conception and design, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Doru Paul – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Ch, Khalil – Conception and design, Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published Ghulam Sajjad Khan – Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published |
|
Guarantor of submission
The corresponding author is the guarantor of submission. |
|
Source of support
None |
|
Conflict of interest
Authors declare no conflict of interest. |
|
Copyright
© Aleksandra Mamorska-Dyga et al. 2013; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
|
|