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Case Report
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| Severe cholestatic jaundice secondary to hyperthyroidism | ||||||
| Yousef Usta1, Julia Massaad1, Samir Parekh1, Laura Knecht2 | ||||||
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1MD, Emory University School of Medicine, Department of Digestive Diseases-Whitehead Biomedical Research Building, 615 Michael Street, Atlanta GA 30322.
2MD, St Joseph Hospital Medical Center, Department of Digestive Diseases-Whitehead Biomedical Research Building, 615 Michael Street, Atlanta GA 30322. | ||||||
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| How to cite this article: |
| Usta Y, Massaad J, Parekh S, Knecht L. Severe cholestatic jaundice secondary to hyperthyroidism. International Journal of Case Reports and Images 2013;4(4):212–215. |
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Abstract
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Introduction:
Hyperthyroidism is a known cause of nonspecific abnormalities in liver biochemitries; most commonly mild elevations in serum bilirubin and liver enzymes.
Case Report: A case of severe cholestatic jaundice secondary to Grave’s disease. The patient is a 28-year-old African-American male who presented to the emergency room with chronic diarrhea, weight loss and jaundice. At presentation, his liver enzymes were elevated in a cholestatic pattern and his bilirubin was 21.4 mg/dL. Upon treatment with propranolol and propylthouracil, his diarrhea, pruritus, jaundice, and liver enzymes quickly improved. His bilirubin returned to normal over a period of two months. Conclusion: While severe intrahepatic cholestasis and jaundice due to hyperthyroidism is rare, the diagnosis should be considered in patients presenting with manifestations of liver disease, as appropriate treatment of hyperthyroidism results in resolution of jaundice. | |
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Keywords:
Hyperthyroidism, Cholestasis, Jaundice
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Author Contributions
Yousef Usta – Substantial contributions and design, Acquisition of data, analysis and interpretation of data, drafting the article, revising it critically for important intellectual content, final approval of the version to be published Julia Massaad – Substantial contributions to analysis and interpretation of data, drafting the article, revising it critically for important intellectual content, final approval of the version to be published Samir Parekh – Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published Laura Knecht – Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© Yousef Usta et al. 2013; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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