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Case Series
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| Basaloid squamous cell carcinoma of the oral cavity: A case series | ||||||
| Kenji Yamagata1, Rei Karube2, Toru Yanagawa3, Wolfgang Zemann4, Philipp Metzler4, Kojiro Onizawa5, Hiroki Bukawa6 | ||||||
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1DDS, Ph.D, Assistant Professor, Department of Oral and Maxillofacial Surgery, Clinical medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
2DDS, Researcher, Department of Oral and Maxillofacial Surgery, Clinical medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. 3MD, DDS, PhD, Associate Professor, Department of Oral and Maxillofacial Surgery, Clinical medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. 4MD, DDS, Consultant, Department of Cranio-Maxillofacial and Oral Surgery, University of Zurich, Zurich, Switzerland. 5DDS, Ph.D, Professor, Department of Oral and Maxillofacial Surgery, Clinical medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. 6MD, DDS, Ph.D, Professor, Department of Oral and Maxillofacial Surgery, Clinical medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. | ||||||
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| How to cite this article: |
| Yamagata K, Karube R, Yanagawa T, Zemann W, Metzler P, Onizawa K, Bukawa H. Basaloid squamous cell carcinoma of the oral cavity: A case series. International Journal of Case Reports and Images 2013;4(4):10–18. |
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Abstract
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Introduction:
Basaloid squamous cell carcinoma (BSCC) has been reported as a highly aggressive, malignant tumor with a high rate of both local recurrence and regional and distant metastases. The purpose of this review is to examine the characteristics and prognosis of BSCC occurring in the oral cavity.
Case Series: We here present three cases of oral BSCC. Case 1: A 49-year-old male was clinically and radiologically classified as T3N0M0 (Stage III). He underwent chemoradiotherapy and more than 8 years after treatment, the patient is alive without evidence of recurrence. Case 2: A 69-year-old female was classified as T4aN0M0 (Stage IVA). She underwent chemoradiotherapy, and died from lung and liver metastasis 4 years and 3 months after her first visit. Case 3: A 73-year-old male was clinically and radiologically classified as T2N2cM0 (Stage IVA). The patient underwent chemoradiotherapy and bilateral neck dissection. More than about 5 years after surgery, the patient is alive without evidence of recurrence. Discussion: About a hundred cases of oral BSCC have been reported, and we review previous reports of oral BSCC cases. Oral BSCC has a lower rate of distant metastasis than head and neck BSCC. Conclusion: In contrast to the aggressive behavior of BSCC occurring in the head and neck, BSCC occurring in the oral cavity appears to have a lower rate of distant metastasis than head and neck BSCC. When it comes to the follow-up of patients for metastases, a more thorough work-up is recommended for patients with oral BSCC than for patients with SCC. | |
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Keywords:
Basaloid squamous cell carcinoma (BSCC), Oral, Cervical lymph node metastasis, Distant metastasis
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Author Contributions:
Kenji Yamagata – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Final approval of the version to be published Rei Karube – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Final approval of the version to be published Toru Yanagawa – Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Wolfgang Zemann – Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Philipp Metzler – Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Kojiro Onizawa – Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Hiroki Bukawa – Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© Kenji Yamagata et al. 2013; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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