Case Report
 
Fournier's gangrene in a pediatric patient after prolonged neglected diarrhea: A case report
Sujoy Neogi1, Piare Lal Kariholu2, Deepak Chatterjee3, Brajesh Kumar Singh4, Rajnish Kumar4
1(DNB Pediatric Surgery), Assistant Professor, Department of Surgery, School of Medical Science and Research & Sharda Hospital Sharda University, Greater Noida, UP, India.
2(MS), Professor, Department of Surgery, School of Medical Science and Research & Sharda Hospital Sharda University, Greater Noida, UP, India.
3(MS), Assistant Professor, Department of Surgery, School of Medical Science and Research & Sharda Hospital Sharda University, Greater Noida, UP, India.
4(MS), Senior Resident, Department of Surgery, School of Medical Science and Research & Sharda Hospital Sharda University, Greater Noida, UP, India.

doi:10.5348/ijcri-2013-02-279-CR-13

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How to cite this article:
Neogi S, Kariholu PL, Chatterjee D, Singh BK, Kumar R. Fournier's gangrene in a pediatric patient after prolonged neglected diarrhea: A case report. International Journal of Case Reports and Images 2013;4(2):135–137.


Abstract
Introduction: Fournier's gangrene in pediatric population is rare and because of low incidence the etiopathogenesis in children is not well known.
Case Report: We report a rare case of a 10-month-old male infant with severe Fournier's gangrene occurring after an episode of prolonged diarrhea. The progression of the disease was very fast and in spite of undergoing a diversion transverse colostomy, the child could not survive.
Conclusion: Fournier's gangrene in children is rare and the course of the illness in our case was very rapid. The relation of this severe form of fasciitis with a common condition like diarrhea is rare and must be known to the treating clinicians.

Keywords: Fournier's gangrene, Perineal ulcer, Pediatric, Diarrhea complication, Necrotizing fasciitis


Introduction

Fournier's gangrene is fascitis of the perineal region commonly seen in adult males with diabetes mellitus. [1] Pediatric involvement is rare. The use of nonsteroidal anti-inflamatory drugs (NSAID) have been found to be associated with Fournier's gangrene in children, besides other causes. [1] [2] [3] [4] [5] [6] In the present case Fournier's gangrene was associated with neglected prolonged diarrhea, perianal excoriation resulting from diarrhea, and poor hygiene which has not been reported in literature so far. The use of NSAID may have also have contributed to the disease.


Case Report

A 10-month-old male infant was brought by his mother to our emergency with a large ulcer in the perianal region for the last 10 days which was extending to the scrotum. The mother also complained that the child had decreased feed tolerance and decreased passage of stools. The child was ill for one month and his illness started with chest retractions, fever and diarrhea. He developed perianal excoriation following diarrhea, the intensity of which kept on increasing. The excoriation turned into a progressive ulcer including the perianal region and the scrotum. The progression of perianal disease was very fast and it reached the present form in only 10 days. (Figure 1) The child kept passing stools which contaminated the wound further. The child had received treatment in the form of antibiotic (amoxycillin) and non-steroidal anti-Inflammatory drugs (NSAID) (Ibuprofen), which were given when the child developed excoriation. On examining the child, the pulse was 150/min (low volume), respiratory rate was 35/min. General physical examination revealed left complete cleft lip with complete cleft palate. The child also had bilateral rhonchi in the chest. Local examination of the perineum revealed a large ulcer measuring 7x5 cm involving the anal canal and the perianal region. The anal canal was retracted up. There was another ulcer at the base of the scrotum measuring 3x4 cm which was superficial extending up to the dartos muscle. The floor of both the ulcers was dirty with extensive sloughing. The hematological report was as follows: hemoglobin 9.7 mg/dL, TLC 9x103/ mm3, platelet count 0.44x106 /mm3, blood urea 20 mg/dL, serum creatinine 0.6 mg/dL, sodium 144 mmol/dL, potassium 2.9 mmol/dL. The pus swab culture reported the growth of klebsiella species. The child was resuscitated adequately with fluids, antibiotics (ceftriaxone, metronidazole and amikacin), platelet transfusion and ionotropes for 24 hours and then posted for emergency transverse colostomy. A colostomy was performed, the ulcer was debrided and the child was catheterized. The child was kept in the intensive care unit on ventilator owing to the poor respiratory efforts in the post-operative period. The condition of the child kept deteriorating and he expired 18 hours after surgery due to multiorgan failure.


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Figure 1: Clinical picture showing the perineal ulceration.



Discussion

Fournier's gangrene is a necrotizing fasciitis of the perineal region. It is progressive and life threatening if not aggressively treated. It is seen more frequently in adults than children and is associated with immunosuppressant factors. [1] Very few cases of Fournier's gangrene have been reported in children [1]. The infection in Fournier's gangrene is polymicrobial and the bacteria act synergistically to produce enzymes such as collagenase and hyaluronidase that invade the fascial planes leading to vascular thrombosis with subsequent gangrene of the overlying skin. [2] The necrotizing fasciitis commonly originates from an infection of the anorectum, urogenital tract or the skin of the genitals. [3] The predisposing factors linked to Fournier's gangrene in children, which are mentioned in literature are NSAIDs use, post varicella infection, diaper rash, prematurity, circumcision, strangulated hernia, testicular torsion, trauma and insect bite. [1] [4] [5] [6] The treatment of Fournier's gangrene in children is equivocal. On one hand some studies favor medical management or conservative surgery in children, [7] [8] [9] others advocate prompt and aggressive surgical debridement. [4] In our case, the child had diarrhea with perianal excoriation which progressed rapidly to a severe debilitating ulcer of the perineum. There was also a history of NSAIDs intake which has been described as a predisposing factor for Fournier's gangrene in children. We speculate in this case that it was the prolonged and neglected diarrhea along with the poor hygiene of the child which contributed to the rapidly developing fasciitis. This case was worth reporting because Fournier's gangrene is uncommon in the pediatric population. Also, the occurrence of this condition following diarrhea is a matter of concern as the incidence of diarrhea in developing countries is very high and therefore development of perianal excoriation should be prevented and promptly treated.


Conclusion

This is the first case report of severe, debilitating Founier's gangrene occurring in a child following prolonged diarrhea. Poor hygiene and improper treatment of the diarrhea have also contribute to the pathology. The role of NSAIDs cannot be confirmed, in causing this condition, although it has been given in our case for the treatment of perianal excoriation.


References
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Author Contributions
Sujoy Neogi – Substantial contributions to conception and design, Acquisition of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Piare Lal Kariholu – Substantial contributions to conception and design, Acquisition of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Deepak Chatterjee – Substantial contributions to conception and design, Acquisition of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Brajesh Kumar Singh – Substantial contributions to conception and design, Acquisition of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Rajnish Kumar – Substantial contributions to conception and design, Acquisition of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
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