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Review Article
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| Cardiovascular adverse effects of metoclopramide: Review of literature |
| Martha M Rumore1 |
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1Assistant Director, Pharmacy Clinical & Educational Services, Cohen Children's Medical Center, North Shore-LIJ, New Hyde Park, N.Y. and Adjunct Professor, Pharmacy & Health Outcomes, Touro College of Pharmacy, New York, N.Y.
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doi:10.5348/ijcri-2012-05-116-RA-1
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Address correspondence to: Dr. Martha M Rumore Cohen Children's Medical Center 420 Lakeville Road New Hyde Park NY - 11040 Phone: Attn: Pharmacy Dept., Ph: (516) 470-8643 Email: mrumore@nshs.edu |
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| How to cite this article: |
| Rumore MM. Cardiovascular adverse effects of metoclopramide: Review of literature. International Journal of Case Reports and Images 2012;3(5):1–10. |
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Abstract
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Introduction:
Articles pertaining to reports and clinical or pharmacological research for cardiovascular adverse effects of metoclopramide were identified via a search of MEDLINE (1966-February 2012), SCOPUS, and Google Scholar.
Objective: To review the reports in literature of patients receiving metoclopramide who sufferred from cardiac arrest, bradycardia, total heart block, acute hypotension, supraventricular tachycardia, circulatory collapse, QT prolongation, Torsade de Pointes, ST depression, and congestive heart failure. Discussion: In most cases the reactions occurred immediately after administration of metoclopramide, were associated with normal doses administered via intravenous or central lines, and resolved. Rechallenge occurred in several cases. The likelihood of these events occurring and the mechanism by which metoclopramide affects the cardiovascular system is unclear, however, it has been shown to have a direct effect on the heart, block presynaptic autoreceptors and enhance catecholamine release, enhance cholinergic neurotransmission and cause 5-HT3 receptor blockade and 5-HT4 receptor antagonism. Conclusion: Due to cardiovascular risks associated with the use of IV metoclopramide, recommendations are to monitor patients and report these events. | |
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Key Words:
Metoclopramide, Cardiovascular, Adverse drug reactions, Case reports, Cardiac
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Author Contributions:
Martha M Rumore - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical Review of the Article, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
Authors declare no conflict of interest. |
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Copyright:
© Martha M Rumore 2012; This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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